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Peter Csermely
Department of Medical Chemistry, Semmelweis University

László Vígh
Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences

About this book

This book is authored by an exciting mixture of top experts and young rising stars from the fields of molecular chaperones and stress adaptation. In addition to giving a comprehensive summary with original references to their field, all authors share their hypotheses and vision on future trends with the reader. The book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. A novel perspective of "old facts" is provided in each chapter, where "old" means only 5-10 years in this rapidly expanding field. The integrative, holistic nature of the book makes it an excellent reading for undergraduates, graduate students and fellow scientists extending their knowledge and studies.

Table of contents

1. Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
R. John Ellis

2. The Cellular "Networking" of Mammalian Hsp27 and Its Functions
in the Control of Protein Folding, Redox State and Apoptosis
André-Patrick Arrigo

3. Molecular Interaction Network of the Hsp90 Chaperone System
Rongmin Zhao and Walid A. Houry

4. Organization of the Functions and Components of the Endoplasmic Reticulum
Yuichiro Shimizu and Linda M. Hendershot

5. Molecular Crime and Cellular Punishment: Active Detoxification of Misfolded
and Aggregated Proteins in the Cell by the Chaperone and Protease Networks
Marie-Pierre Hinault and Pierre Goloubinoff

6. Chaperones as Parts of Cellular Networks
Peter Csermely, Csaba Söti and Gregory L. Blatch

7. Chaperones as Parts of Organelle Networks
György Szabadkai and Rosario Rizzuto

8. Heat Shock Factor 1 As a Coordinator of Stress and Developmental Pathways
Julius Anckar and Lea Sistonen

9. Chaperone Regulation of the Heat Shock Protein Response
Richard Voellmy and Frank Boellmann

10. Mechanisms of Activation and Regulation of the Heat Shock-Sensitive
Signaling Pathways
Sébastien Ian Nadeau and Jacques Landry

11. Membrane-Regulated Stress Response: A Theoretical and Practical Approach
László Vígh, Zsolt Török, Gábor Balogh, Attila Glatz, Stefano Piotto and Ibolya Horváth

12. Beyond the Lipid Hypothesis: Mechanisms Underlying Phenotypic Plasticity
in Inducible Cold Tolerance
Scott A.L. Hayward, Patricia A. Murray, Andrew Y. Gracey and Andrew R. Cossins

13. Trehalose As a "Chemical Chaperone": Fact and Fantasy
John H. Crowe

14. Chaperones As Part of Immune Networks
Zoltán Prohászka

15. The Stress of Misfolded Proteins: C. elegans Models for Neurodegenerative
Disease and Aging
Heather R. Brignull, James F. Morley and Richard I. Morimoto

16. Hsp90 and Developmental Networks
Suzannah Rutherford, Jennifer R. Knapp and Peter Csermely