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Peter Sutovsky
University of Missouri-Columbia
Columbia, Missouri, U.S.A.

About this book

Topics discussed include recent progress in pig SCNT and production of transgenic and knock out pigs for biomedical research and xenotransplantation, cattle cloning, behavioral studies in cloned mice, nuclear remodeling and imprinting, cell cycle regulation, nucleolar biogenesis, the effect of artificial activation on early development of cloned embryos, and inheritance of mitochondrial DNA and centrosome. Altogether, the present tome provides the reader with a unique developmental, molecular and cell biological view of the exciting SCNT technology, while also discussing its pitfalls and possible future directions and detours. Somatic Cell Nuclear Transfer will help both students and experienced researchers to further develop their knowledge and understanding of mammalian embryonic development.

Table of contents

1. Nuclear Remodeling and Nuclear Reprogramming for Making
Transgenic Pigs by Nuclear Transfer
Randall S. Prather

2. Somatic Cell Nuclei in Cloning: Strangers Traveling in a Foreign Land
Keith E. Latham, Shaorong Gao and Zhiming Han

3. Cloning Cattle: The Methods in the Madness
Björn Oback and David N. Wells

4. Centrosome Inheritance after Fertilization and Nuclear Transfer in Mammals
Qing-Yuan Sun and Heide Schatten

5. Developmental, Behavioral, and Physiological Phenotype of Cloned Mice
Kellie L.K. Tamashiro, Randall R. Sakai, Yukiko Yamazaki, Teruhiko Wakayama
and Ryuzo Yanagimachi

6. Nucleolar Remodeling in Nuclear Transfer Embryos
Jozef Laurincik and Poul Maddox-Hyttel

7. Somatic Cell Nuclear Transfer (SCNT) in Mammals: The Cytoplast
and Its Reprogramming Activities
Josef Fulka, Jr. and Helena Fulka

8. Mitochondrial DNA Inheritance after SCNT
Stefan Hiendleder

9. Activation of Fertilized and Nuclear Transfer Eggs
Christopher Malcuit and Rafael A. Fissore