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Christine Chaponnier
University of Geneva
Geneva, Switzerland

Alexis Desmouliere
University of Bordeaux 2
Bordeaux, France

Giulio Gabbiani
University of Geneva
Geneva Switzerland

About this book

Tissue Repair, Contraction and the Myofibroblast summarizes the most recent findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. This recent work shows that the myofibroblast is responsible for the development of pathological situations such as hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma.

Table of contents

Introduction–The Evolution of the Concept of Myofibroblast: Implications for Normal
and Pathological Tissue Remodeling
Alexis Desmoulière, Christine Chaponnier and Giulio Gabbiani

1. Cytomechanics in Connective Tissue Repair and Engineering
Robert A. Brown

2. Scleroderma Lung Fibroblasts: Contractility and Connective Tissue
Growth Factor
Galina S. Bogatkevich, Anna Ludwicka-Bradley, Paul J. Nietert
and Richard M. Silver

3. Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1
Carolyn J. Baglole, Terry J. Smith, David Foster, Patricia J. Sime,
Steve Feldon and Richard P. Phipps

4. Tissue Repair in Asthma: The Origin of Airway Subepithelial Fibroblasts
and Myofibroblasts
Sabrina Mattoli

5. Experimental Models to Study the Origin and Role of Myofibroblasts
in Renal Fibrosis
Michael Zeisberg, Mary A. Soubasakos and Raghu Kalluri

6. Epithelial to Mesenchymal Transition of Mesothelial Cells as a Mechanism
Responsible for Peritoneal Membrane Failure in Peritoneal Dialysis Patients
Abelardo Aguilera, Luiz S. Aroeira, Marta Ramírez-Huesca,
José A. Jiménez-Heffernan, Rafael Selgas and Manuel López-Cabrera

7. FIZZy Alveolar Epithelial Cells Induce Myofibroblast Differentiation
Sem H. Phan

8. Pro-Invasive Molecular Cross-Signaling between Cancer Cells
and Myofibroblasts
Olivier De Wever and Marc Mareel

9. Proangiogenic Implications of Hepatic Stellate Cell Transdifferentiation
into Myofibroblasts Induced by Tumor Microenvironment
Elvira Olaso, Beatriz Arteta, Clarisa Salado, Eider Eguilegor, Natalia Gallot,
Aritz Lopategi, Virginia Gutierrez, Miren Solaun, Lorea Mendoza
and Fernando Vidal-Vanaclocha

10. Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase
and Matrix Turnover and the Fate of Hepatic Stellate Cells
Aqeel M. Jamil and John P. Iredale

11. Innate Immune Regulation of Lung Injury and Repair
Dianhua Jiang, Jennifer Hodge, Jiurong Liang and Paul W. Noble

12. An Eye on Repair: Myofibroblasts in Corneal Wounds
James V. Jester