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TNF Receptor Associated Factors (TRAFs)


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Hao Wu
Department of Biochemistry, Weill Medical College of Cornell University

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-387-70629-0
Pub date: 2007-06-08
206 pages
46 figures
7 tables
16 color pages

About this book

This book is currently the only piece of literature entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions, as well as in viral infection. The book is intended for a wide audience, including researchers in the field of TRAF signaling, and students and postdoctoral fellows learning cell biology and cell signal transduction. This book is up to date on the most recent advances in TRAF signal transduction.

Table of contents

Foreword
Vishva M. Dixit

1. Phylogeny of the TRAF/MATH Domain
Juan M. Zapata, Vanesa Martínez-García and Sophie Lefebvre

2. TRAF1 and Its Biological Functions
Soo Young Lee and Yongwon Choi

3. Physiological Roles and Mechanisms of Signaling by TRAF2
and TRAF5
Ping-Yee Billie Au and Wen-Chen Yeh

4. TRAF3 and Its Biological Function
Jeannie Q. He, Gagik Oganesyan, Supriya K. Saha, Brian Zarnegar
and Genhong Cheng

5. TRAF4, the Unique Family Member
Valérie Kedinger and Marie-Christine Rio

6. Characteristics and Biological Functions of TRAF6
Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama

7. Ubiquitination and TRAF Signaling
Gabriel Pineda, Chee-Kwee Ea and Zhijian J. Chen

8. Structural Revelations of TRAF2 Function in TNF Receptor
Signaling Pathway
Jee Y. Chung, Miao Lu, Qian Yin and Hao Wu

9. Protein-Protein Interactions in TRAF3
Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu

10. Molecular Basis for the Unique Specificity of TRAF6
Jee Y. Chung, Miao Lu, Qian Yin, Su-Chang Lin and Hao Wu

11. TRAF Proteins in CD40 Signaling
Gail A. Bishop, Carissa R. Moore, Ping Xie, Laura L. Stunz
and Zachary J. Kraus

12. TRAFs in RANK Signaling
Bryant G. Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe
and Jörg J. Jacoby

13. The LTbR Signaling Pathway
Paula S. Norris and Carl F. Ware

14. LMP1 TRAFficking Activates Growth and Survival Pathways
Vishal Soni, Ellen Cahir-McFarland and Elliott Kieff

15. Targeting TRAFs for Therapeutic Intervention
Juan M. Zapata, Sophie Lefebvre and John C. Reed