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Maurizio Fanciulli
Regina Elena Cancer Institute
Rome, Italy

About this book

Rb and Tumorigenesis examines how recent advances have demonstrated the interaction of Rb with chromatin remodeling enzymes. This new title explores the potential roles of these interactions in Rb functions and provides some evidence that distinct Rb co-repressor may target different genes in different phases of the cell cycle.

Table of contents

1. RB as a Positive Transcriptional Regulator during Epithelial Differentiation
Chantal E. Crémisi and Linda L. Pritchard

2. pRb in the Differentiation of Normal and Neoplastic Cells
Deborah Pajalunga, Grazia Camarda and Marco Crescenzi

3. Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein
Erik S. Knudsen and Steven P. Angus

4. New Insights into Transcriptional Regulation by Rb: One Size No Longer Fits All
Peggy J. Farnham

5. Regulation of Rb Function by Noncyclin Dependent Kinases
Jaya Padmanabhan and Srikumar P. Chellappan

6. Diverse Regulatory Functions of the E2F Family of Transcription Factors
Fred Dick and Nicholas Dyson

7. Regulation of E2F-Responsive Genes through Histone Modifications
Estelle Nicolas, Laetitia Daury and Didier Trouche

8. Emerging Roles for the Retinoblastoma Gene Family
Jacqueline L. Vanderluit, Kerry L. Ferguson and Ruth S. Slack

9. Rb and Cellular Differentiation
Lucia Latella and Pier Lorenzo Puri