Nucleic Acid Switches and Sensors
|
Email this
Print this
Scott K. Silverman
This book is co-published with Springer.
Please click here to purchase this book at the Springer site. ISBN: 978-0-387-37491-8 Pub date: 2006-08-25 125 pages 57 figures 2 tables |
About this bookIn this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed. |
|
Table of contentsSECTION I: ARTIFICIAL NUCLEIC ACID SWITCHES AND SENSORS 1. Allosteric Ribozymes as
Molecular Switches and Sensors 2. Ribozymes and Deoxyribozymes
Switched by Oligonucleotides 3. Ribozymes Switched by Proteins 4. Fluorescence-Signaling
Nucleic Acid-Based Sensors SECTION II: NATURAL NUCLEIC ACID SWITCHES AND SENSORS 5. Protein-Induced RNA Switches
in Nature 6. Riboswitches as Genetic
Control Elements 7. Switchable RNA Motifs as
Drug Targets |
|