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Anthony J. Koleske
Yale University
New Haven, Connecticut, U.S.A.

About this book

Abl family nonreceptor tyrosine kinases serve as essential relays between the world outside of the cell and the cellular machinery that coordinates changes in cytoskeletal structure, regulates cell division, responds to DNA damage, and executes programmed cell death. Mutational activation of these kinases subverts normal cellular controls on these processes and leads to human leukemia. The book is a compilation of what we presently know about the cellular and molecular mechanisms by which Abl family kinases function in development and how dysregulation of these processes causes leukemia in humans and developmental defects in animals.

Table of contents

1. Mechanisms of Activation of Abl Family Kinases
Oliver Hantschel and Giulio Superti-Furga

2. Role of Abl Family Kinases in Growth Factor-Mediated Signaling
Ann Marie Pendergast

3. Regulation of Cell Adhesion Responses by Abl Family Kinases
Keith Quincy Tanis and Martin Alexander Schwartz

4. Abl and Cell Death
Jean Y.J. Wang, Yosuke Minami and Jiangyu Zhu

5. Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
Anthony J. Koleske

6. Regulation of Cell Motility by Abl Family Kinases
Shahin Emami and Richard L. Klemke

7. Oncogenic Forms of ABL Family Kinases
Ruibao Ren

8. Abl Family Kinases in Mammalian Development
Eva Marie Y. Moresco

9. Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity
Cheryl L. Thompson and David Van Vactor