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Mark D. Evans
University of Leicester
Leicester, U.K.

Marcus S. Cooke
University of Leicester

About this book

Inspiration for this book came from a review written for Bioessays, entitled ‘Factors affecting the outcome of oxidative damage to DNA’. The premise of the review was that there is a growing amount of literature examining the effects of oxidative damage to DNA, other than mutation. This includes the effects of damage in transcription factor binding sites, how oxidation in CpG islands alters methylation patterns, and evidence that oxidants promote microsatellite instability and even accelerate telomere attrition. In this volume, the original authors of the articles cited in Bioessays have been brought together, enabling a ‘first hand’ description of their contributions to this most interesting area of DNA damage. One notable exception is the subject of gene-specific damage to DNA. For over ten years, this subject has received intermittent attention, largely due to the complexity of the techniques involved. This nevertheless remains an important issue. In Bioessays, additional focus was provided upon both non-coding, as well as coding, regions of the genome. This work effectively rubbishes the term ‘junk’ DNA, if you’ll forgive the pun, as the term ‘junk’ implies ‘of no significance’. On the contrary, damage to non-coding sites can be an important event in the pathogenesis of disease.

Table of contents

1. Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects
Jean Cadet, Thierry Douki, Carine Badouard, Alain Favier and Jean-Luc Ravanat

2. Chlorination and Nitration of DNA and Nucleic Acid Components
Clare L. Hawkins, David I. Pattison, Matthew Whiteman and Michael J. Davies

3. Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides
Yusaku Nakabeppu, Mehrdad Behmanesh, Hiroo Yamaguchi, Daisuke Yoshimura
and Kunihiko Sakumi

4. Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle
Oxidative DNA Damage
Sophie Couvé-Privat, Alexander A. Ishchenko, Jacques Laval and Murat Saparbaev

5. OGG1: From Structural Analysis to the Knockout Mouse
Arne Klungland, Jon K. Laerdahl and Torbjørn Rognes

6. Processing of 3’-End Modified DNA Strand Breaks Induced
by Oxidative Damage
Jason L. Parsons, Emma Boswell and Grigory L. Dianov

7. Oxidative Damage and Promoter Function
David Mitchell and Rita Ghosh

8. Oxidative DNA Damage and Telomere Shortening
Torsten Richter and Thomas von Zglinicki

9. Oxidative Damage and Repair in the Mitochondrial Genome
Lene Juel Rasmussen and Keshav K. Singh

10. The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis
of Neurological Disease
V. Prakash Reddy, Ayse Beyaz, George Perry, Marcus S. Cooke, Lawrence M. Sayre
and Mark A. Smith

11. Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases
Maria Grazia Andreassi

12. Oxidative DNA Damage and Carcinogenesis
Ryszard Olinski, Marek Foksinski and Barbara Tudek

13. The Physiological and Pathological Roles of Oxidative Damage to DNA
in Relation to Life Stage
Alberto Izzotti

14. Analysis of 8-Hydroxy-2’-Deoxyguanosine as a Marker of Oxidatively
Damaged DNA in Relation to Carcinogenesis and Aging
H. Kasai, T. Hirano, K. Kawai, Y. Tsurudome, H. Itoh, D. Himeji and T. Horiuchi

15. Oxidatively Damaged DNA and Inflammation
Peter C. Dedon and Marita C. Barth

16. The Role of Antioxidants in the Prevention of Oxidative Damage
to Nucleic Acids
Peter Møller and Steffen Loft