Email this

Print this

Alexander Burkle
University of Konstanz
Konstanz, Germany

About this book

The research field of poly(ADP-ribosyl)ation, which originated in the mid-1960s as an extremely narrow focus of interest for polynucleotide biochemists, has remained a rather stable field for a long time in terms of scientific orientation and researchers involved. Starting from the late 1980s, however, the scene has witnessed a tremendous influx of new people, fresh ideas and novel techniques, which led—especially over the last five years—to a breathtaking expansion of the field with regards to breadth and depth of scientific information available. What began as a peculiar posttranslational modification somehow associated with DNA repair has now invaded almost all sub-disciplines of biology and has also gained substantial interest by medical researchers and pharmaceutical companies, as there is a wide range of pathophysiological conditions linked with poly(ADP-ribosyl)ation. Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.

Table of contents

1. Enzymes in Poly(ADP-Ribose) Metabolism
Ralph G. Meyer, Mirella L. Meyer-Ficca, Elaine L. Jacobson and Myron K. Jacobson

2. PARP-2: Structure-Function Relationship
Valérie Schreiber, Michelle Ricoul, Jean-Christophe Amé, Françoise Dantzer,
Véronique Meder, Catherine Spenlehauer, Patrick Stiegler, Claude Niedergang,
Laure Sabatier, Vincent Favaudon, Josiane Ménissier-de Murcia and Gilbert de Murcia

3. Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals
Ulrich Cortes and Zhao-Qi Wang

4. DNA Damage Signaling through Poly(ADP-Ribose)
Maria Malanga and Felix R. Althaus

5. Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome
Duplication and in the Maintenance of Neuronal Integrity
Masanao Miwa, Masayuki Kanai, Masahiro Uchida, Kazuhiko Uchida and Shuji Hanai

6. Functional Interactions of PARP-1 with p53
Rafael Alvarez-Gonzalez, Hanswalter Zentgraf, Manfred Frey and Hilda Mendoza-Alvarez

7. Dynamic Interaction between PARP-1, PCNA and p21(waf1/cip1)
Ennio Prosperi and A. Ivana Scovassi

8. PARP-1 as Novel Coactivator of NF-kB in Inflammatory Disorders
Paul O. Hassa and Michael O. Hottiger

9. PARP and Epigenetic Regulation
Paola Caiafa

10. PARP and the Release of Apoptosis-Inducing Factor from Mitochondria
Suk Jin Hong, Ted M. Dawson and Valina L. Dawson

11. Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated
Event in Apoptosis
A. Hamid Boulares, Alexander G. Yakovlev and Mark E. Smulson

12. NAD-Metabolism and Regulatory Functions
Mathias Ziegler

13. PARP-1 and the Shape of Cell Death
László Virág

14. Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity
Domenico E. Pellegrini-Giampietro, Alberto Chiarugi and Flavio Moroni

15. Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury
Prabal K. Chatterjee and Christoph Thiemermann

16. Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis
of Inflammation and Circulatory Shock
Csaba Szabó

17. Role of Poly-ADP-Ribosylation in Cancer Development
Mitsuko Masutani, Akemi Gunji, Masahiro Tsutsumi, Kumiko Ogawa, Nobuo Kamada,
Tomoyuki Shirai, Kou-ichi Jishage, Hitoshi Nakagama and Takashi Sugimura

18. PARP Inhibitors and Cancer Therapy
Nicola J. Curtin

19. Poly(ADP-Ribosyl)ation and Aging
Sascha Beneke and Alexander Bürkle