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Rise and Fall of Epithelial Phenotype:
Concepts of Epithelial-Mesenchymal Transition


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Pierre Savagner
Equipe Genome et Cancer - CNRS - Montpellier

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-306-48239-7
Pub date: 2005-06-07
324 pages
101 figures
2 color pages

Table of contents

1. EMT Concept and Examples from the Vertebrate Embryo
Elizabeth D. Hay

2. Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic Events
Occurring during Early Development
Olivier G. Morali, Pierre Savagner and Lionel Larue

3. The Neural Crest: A Model Developmental EMT
Donald F. Newgreen and Sonja J. McKeown

4. Epithelial-Mesenchymal Transformation in the Embryonic Heart
Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch and Scott E. Klewer

5. Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra
Michael P. Sarras, Jr.

6. Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos
Gary M. Wessel and Hideki Katow

7. Change of Epithelial Fate: Lessons from Gastrulation in Drosophila
Atish Ganguly and Y. Tony Ip

8. Cutaneous Wound Reepithelialization: A Partial and Reversible EMT
Valérie Arnoux, Christophe Côme, Donna F. Kusewitt, Laurie G. Hudson
and Pierre Savagner

9. Epithelial-Mesenchymal Transitions in Human Cancer
Veerle L. Van Marck and Marc E. Bracke

10. Structural and Functional Regulation of Desmosomes
Spiro Getsios, Lisa M. Godsel and Kathleen J. Green

11. Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E-Cadherin
Geert Berx and Frans Van Roy

12. The Regulation of Catenins in Cancer
Maralice Conacci-Sorrell and Avri Ben-Ze’ev

13. Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease
Regina M. Day, Angelina Felici and Donald P. Bottaro

14. The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition
Sylvia Julien-Grille, Robert Moore, Laurence Denat, Olivier G. Morali, Véronique Delmas, Alfonso Bellacosa and Lionel Larue

15. TGFβ-Dependent Epithelial-Mesenchymal Transition
Marie-Luce Vignais and Patrick Fafet

16. The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering
Brigitte Boyer

17. Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases
Masato Nakagawa, Nanae Izumi and Kozo Kaibuchi

18. Wnt Signaling Networks and Embryonic Patterning
Michael W. Klymkowsky

19. Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network
Cécile Gauthier-Rouvière, Marie Causeret, Franck Comunale and Sophie Charrasse

20. Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition:
Implications for Carcinoma Metastasis
Christine Gilles, Donald F. Newgreen, Hiroshi Sato and Erik W. Thompson