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Alan R. Saltiel
Life Sciences Institute


Jeffrey E. Pessin
State University of New York at Stony Brook

About this book

The purpose of this book is to gather together several renowned experts to produce a monograph on Insulin Action. The articles herein provide novel insight into the key issues underlying the molecular biology of insulin action and insulin resistance. De Meyts et al, cover the structure and function of insulin and insulin-like growth factor receptors. Watson and colleagues outline the events at the intersection of signal transduction and vesicle trafficking that are crucial to the stimulation of glucose uptake by insulin. Debbie Thurmond reviews the important events that occur when glut4 vesicles dock and fuse at the plasma membrane. Christian and Lawrence comment on the mechanisms responsible for the regulation of protein synthesis by insulin, while Clark and Newgard review those mechanisms responsible for changes in hepatic fuel metabolism. Because gene expression is so important in metabolism, Sutherland et al, outline the steps that are involved in the regulation of transcription by insulin. As the primary event in metabolic control, Kulkarni describes how the beta cell is regulated by insulin, and in related work, Obici and Rossetti cover the central control of peripheral insulin sensitivity. Much progress in studies of insulin action has been made in animal models, and Oriente and Accili review transgenic and knock out models of insulin action and resistance. Finally, Courtney and Olefsky review the occurrence and treatment of insulin resistance. Together, these authors have provided a comprehensive summary of our understanding of insulin action from cellular physiology to the integration of tissue specific signaling events that are responsible for whole body glucose homeostasis.

Table of contents

1. Insulin and IGF-I Receptor Structure and Binding Mechanism
Pierre De Meyts, Waseem Sajid, Jane Palsgaard, Anne-Mette Jensen,
Hassan Aladdin and Jonathan Whittaker

2. Subcellular Compartmentalization of Insulin Signaling Processes
and GLUT4 Trafficking Events
Robert T. Watson, Alan R. Saltiel, Jeffrey E. Pessin and Makoto Kanzaki

3. Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated
Vesicle Exocytosis
Debbie C. Thurmond

4. Control of Protein Synthesis by Insulin
Joseph F. Christian and John C. Lawrence, Jr.

5. Hepatic Regulation of Fuel Metabolism
Catherine Clark and Christopher B. Newgard

6. Insulin Action Gene Regulation
Calum D. Sutherland, Richard M. O’Brien and Daryl K. Granner

7. Insulin Action in the Islet β-Cell
Rohit N. Kulkarni

8. Central Regulation of Insulin Sensitivity
Silvana Obici and Luciano Rossetti

9. Transgenic Models of Impaired Insulin Signaling
Francesco Oriente and Domenico Accili

10. Insulin Resistance
C. Hamish Courtney and Jerrold M. Olefsky