Email this

Print this

Francesco M. Marincola
National Institutes of Health

List price: $149.00
add book to cart

pdf price: $99.00
add pdf to cart.


ISBN: 978-1-58706-285-8
Pub date: 2006-01-26
206 pages
31 figures
22 tables

About this book

Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-tumor effects whether IL-10 is locally (tumor transfectant models) or systemically (transgenic models, administration of soluble cytokine) provided. In addition, recent work has suggested that polymorphisms of the promoter region of IL-10 may segregate propulsions in high and low producers. Surprisingly, high IL-10 producers may be more predisposed to acquire cancer and other diseases. Finally, human observations demonstrate that systemic administration of IL-10 to normal volunteers is associated with very little toxicity and pro-inflammatory properties mediated through activation of effector cells of the innate immune response. Thus, the role that interleukin-10 plays in vivo in physiological or pathological conditions remains controversial. Thus, there exists a compelling need to summarize in a book the state of the science of this important cytokine. With the assistance of several experts in this field, Interleukin-10 has attempted this endeavor.

Table of contents

I. INTERLEUKIN-10

1A. Structure and Function of IL-10 and the IL-10 Receptor
Alexander Zdanov

1B. IL-10 Effects on Innate Immunity
Shin-ichiro Fujii and Michael T. Lotze

1C. Interleukin-10 and Adaptive Immune Response
Simone Mocellin, Carlo Riccardo Rossi and Pierluigi Pilati

II. EXPERIMENTAL MODELS FOR THE ANALYSIS OF IL-10 FUNCTION

2. Experimental Models for the Analysis of IL-10 Function
Carl G. Feng, Julio Aliberti, Karl F. Hoffmann, Dragana Jankovic, Marika C. Kullberg, Alan Sher
and Thomas A. Wynn

III. GENETIC POLYMORPHISM OF IL-10 AND RELEVANCE TO IMMUNE FUNCTION

3A. Role of IL-10 in Autoimmune Pathology
Lionel Almeras and Lionel Prin

3B. Interleukin-10 Gene Polymorphisms and Cancer
W. Martin Howell

3C. IL-10 Gene Polymorphisms in Transplantation
Andrey Morgun, Natalia Shulzhenko and Maria Gerbase-DeLima

3D. IL-10, Genetic Polymorphism and Its Relevance to Age-Related Diseases
Domenico Lio and Calogero Caruso

IV. IL-10 IN INFECTION AND INFLAMMATION

4. IL-10: Role in Infectious Diseases
M. Kryworuchko, W. David Creery and Ashok Kumar

V. ROLE OF IL-10 IN ALLERGY

5. Interleukin-10 in Allergic Disease
Peter J. Barnes

VI. ROLE OF IL-10 IN AUTOIMMUNE PATHOLOGY

6. The Role of IL-10 in Autoimmune Pathology
Andrew W. Gibson, Jeffrey C. Edberg, Jianming Wu and Robert P. Kimberly

VII. ROLE OF IL-10 IN TRANSPLANTATION

7. Role of Interleukin-10 in Transplantation
Thomas Ritter and Hans-Dieter Volk

VIII. ROLE OF IL-10 IN INFLAMMATORY DISEASE

8A. Role of IL-10 in Reactive Arthritis and Ankylosing Spondylitis
Joachim Sieper and Martin Rudwaleit

8B. Interleukin-10 and Psoriasis
Khusru Asadullah, W. Sterry and Hans-Dieter Volk

8C. IL-10: The Role in Crohn’s Disease
James Lindsay

8D. IL-10 and Systemic Lupus Erythematosus
Simone Mocellin

IX. ROLE OF IL-10 IN CANCER

9. Role of IL-10 in Cancer
Monica C. Panelli and Francesco M. Marincola