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Shiro Iuchi
Harvard University

Natalie Kuldell
MIT

Table of contents

1. The Discovery of Zinc Fingers and Their Practical Applications
in Gene Regulation: A Personal Account
Aaron Klug

SECTION 1. BINDING OF ZINC FINGERS TO DNA

2. C₂H₂ Zinc Fingers As DNA Binding Domains
Shiro Iuchi

3. TFIIIA: A Sophisticated Zinc Finger Protein
Raymond S. Brown and Jane Flint

4. GAGA: Structural Basis for Single Cys₂His₂ Zinc Finger-DNA Interaction
G. Marius Clore and James G. Omichinski

5. The DNA-Binding Domain of GATA Transcription Factors–
A Prototypical Type IV Cys₂-Cys₂ Zinc Finger
Angela M. Gronenborn

6. MutM: Single C₂C₂ Zinc Finger-DNA Interaction
Ryoji Masui, Noriko Nakagawa and Seiki Kuramitsu

7. Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function
Patrick Van Roey, Marlene Belfort and Victoria Derbyshire

8. Zinc Finger Interactions with Metals and Other Small Molecules
Jay S. Hanas, Jason L. Larabee and James R. Hocker

9. Synthetic Zinc Finger Transcription Factors
Nicoletta Corbi, Valentina Libri and Claudio Passananti

SECTION 2. BINDING OF ZINC FINGERS TO RNA

10. TFIIIA and p43: Binding to 5S Ribosomal RNA
Paul J. Romaniuk

11. RNA Binding by Single Zinc Fingers
Martyn K. Darby

12. Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA
Cristina Mendez-Vidal, Fredrik Hellborg, Margareta T. Wilhelm, Magdalena Tarkowska
and Klas G. Wiman

13. Tandem CCCH Zinc Finger Proteins in mRNA Binding
Perry J. Blackshear, Ruth S. Phillips and Wi S. Lai

14. Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a
John Dresios, Yuen-Ling Chan and Ira G. Wool

SECTION 3. BINDING OF ZINC FINGERS TO PROTEINS

15. LIM Domain and Its Binding to Target Proteins
Algirdas Velyvis and Jun Qin

16. RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation
Kazuhiro Ikeda, Satoshi Inoue and Masami Muramatsu

17. Structure and Function of the CBP/p300 TAZ Domains
Roberto N. De Guzman, Maria A. Martinez-Yamout, H. Jane Dyson and Peter E. Wright

18. A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2
Odile Filhol, Maria José Benitez and Claude Cochet

SECTION 4. BINDING OF ZINC FINGERS TO SMALL MOLECULES

19. The FYVE Finger: A Phosphoinositide Binding Domain
Harald Stenmark

SECTION 5. COMMON DOMAINS PRESENT IN ZINC FINGER PROTEINS

20. The BTB Domain Zinc Finger Proteins
Gilbert G. Privé, Ari Melnick, K. Farid Ahmad and Jonathan D. Licht

21. KRAB Zinc Finger Proteins: A Family of Repressors Mediating Heterochromatin-Associated Gene Silencing
Shiro Iuchi

22. The Superfamily of SCAN Domain Containing Zinc Finger Transcription
Factors Tucker Collins and Tara L. Sander

SECTION 6. BIOLOGY OF ZINC FINGER PROTEINS

23. Sp1 and Huntington’s Disease
Dimitri Krainc

24. The Role of WT1 in Development and Disease
Sean Bong Lee, Hongjie Li and Ho-Shik Kim

25. Yin Yang 1
Huifei Liu and Yang Shi

26. The Multiple Cellular Functions of TFIIIA
Natalie Kuldell

27. The Role of the Ikaros Gene Family in Lymphocyte Development
Pablo Gómez-del Arco, Taku Naito, John Seavitt, Toshimi Yoshida, Christine Williams
and Katia Georgopoulos

28. Basonuclin: A Zinc Finger Protein of Epithelial Cells and Reproductive Germ Cells
Howard Green and Hung Tseng

29. ZAS Zinc Finger Proteins: The Other κB-Binding Protein Family
Carl E. Allen and Lai-Chu Wu

30. Role of GATA Factors in Development
Marc Haenlin and Lucas Waltzer

31. The Androgen Receptor and Spinal and Bulbar Muscular Atrophy
Federica Piccioni, Charlotte J. Sumner and Kenneth H. Fischbeck

32. The Role of XPA in DNA Repair
Takahisa Ikegami and Masahiro Shirakawa

33. MOF, an Acetyl Transferase Involved in Dosage Compensation in Drosophila,
Uses a CCHC Finger for Substrate Recognition
Asifa Akhtar and Peter B. Becker