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Shamim I. Ahmad
Nottingham Trent University
Nottingham, England

Sandra H. Kirk
School of Science and Technology, Nottingham Trent University

About this book

Fanconi anemia (FA) is a rare largely autosomal recessive genetic disorder (one complementation group being X?linked) that was first recognized almost 40 years ago as a cause of juvenile leukemia. Other phenotypes include bone marrow failure leading to aplastic anemia, growth retardation, congenital malformations of renal, cardiac, skeletal and skin structures, pancytopenia and pronounced cancer predisposition. Working with the leading researchers and clinicians in the field, this book has been produced to provide a comprehensive treatise on FA. This covers in detail what is known of the 12 complementation groups identified to date. Molecular Mechanisms of Fanconi Anemia will give research students a platform for further investigation, and act as a source of information regarding experimental design. Clinicians will find this title useful for its comprehensive description of Fanconi Anemia and information on the latest molecular theories underlying its causes.

Table of contents

1. Clinical Features of Fanconi Anaemia
A. Malcolm R. Taylor

2. The Genetic Basis of Fanconi Anemia
Grover C. Bagby, Jr.

3. The FANCA Gene and Its Products
Laura S. Haneline

4. The FANCC Gene and Its Products
Susan M. Gordon and Manuel Buchwald

5. The FANC B, E, F and G Genes and Their Products
Filippo Rosselli

6. FANCD1/BRCA2 and FANCD2
Gary M. Kupfer

7. The FANC Genome Surveillance Complex
Takayuki Yamashita

8. Other Proteins and Their Interactions with FA Gene Products
Tetsuya Otsuki and Johnson M. Liu

9. Fanconi Anaemia and Oxidative Stress: Cellular and Clinical Phenotypes
Giovanni Pagano and Shamim I. Ahmad

10. Therapy for Fanconi Anemia
Madeleine Carreau

11. Mutational Analyses of Fanconi Anemia Genes in Japanese Patients
Akira Tachibana