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Lentiviral Vector Systems
for Gene Transfer


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Gary L. Buchschacher
University of California-San Diego

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-306-47702-7
Pub date: 2003-01-01
196 pages
25 figures
22 tables

About this book

This volume is designed to summarize recent progress in the development of lentiviral vectors for in vitro gene transfer studies and for subsequent animal and human clinical studies. Although lentiviral vector systems may offer some advantage over previously studied viral vector systems for use in potential gene therapy applications, such vectors also present technological hurdles that must be overcome and raise unique concerns that must be addressed as the vector systems are developed and potentially applied to clinical gene transfer studies.

Table of contents

Chapter 1—Introduction to Retrovirus Replication and Retroviral Vectors
Gary L. Buchschacher, Jr.,

Chapter 2—HIV-1 Replication
 Eric O. Freed

Chapter 3—Determinants of Infection of Non-dividing Cells
 Marie Vodicka

Chapter 4—HIV-1 Vectors
 Narasimhachar Srinivasakumar

Chapter 5—HIV-2 and SIV Vectors
 James Gilbert and Flossie Wong-Staal

Chapter 6—FIV Vectors
 Sybille L. Sauter, Ph.D. and Mehdi Gasmi

Chapter 7—EIAV, CAEV, and Other Lentiviral Vectors
 John C. Olsen

Chapter 8—Safety Considerations in Vector Development
 John C. Kappes, Ph.D. and Xiaoyun Wu

Chapter 9—Prospects for Gene Therapy Using HIV-Based Vectors
 John Zaia, M.D. and Jiing-Kuan Yee

Chapter 10—Ethical Considerations in the Use of Lentiviral Vectors for genetic Transfer
 Ina Roy, M.D.