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Hiroshi Handa
Tokyo Institute of Technology
Nagatsuta, Yokohama, Japan


Yuki Yamaguchi
Tokyo Institute of Technology
Nagatsuta, Yokohama, Japan

About this book

Since its discovery in 1979, HDV has occupied a unique position in virus taxonomy. It does not belong to any of the established viral family but constitutes its own genus, deltavirus, whereas it does have significant similarity to viroids, subviral agents of higher plants. HDV RNA genome is smaller than any known animal virus genome, so small that it encodes only a single protein. Therefore, its propagation is largely dependent on factors supplied by host and another virus, hepatitis B virus (HBV). Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this book describes one of the broad aspects of HDV from virology to molecular biology, and from diagnosis to therapy.

Table of contents

1. Genotype of Hepatitis Delta Virus
Nobuyuki Enomoto, Hideki Watanabe, Kazuyoshi Nagayama, Tsuyoshi Yamashiro and Mamoru Watanabe

2. Hepatitis Delta Virus: HDV-HBV Interactions
Camille Sureau

3. Structure and Replication of Hepatitis Delta Virus RNA
John M. Taylor

4. Hepatitis Delta Antigen: Biochemical Properties and Functional Roles in HDV Replication
Michael M.C. Lai

5. Hepatitis Delta Virus RNA Editing
John L. Casey

6. Hepatitis Delta Antigen and RNA Polymerase II
Yuki Yamaguchi and Hiroshi Handa

7. Clinical Features of Hepatitis Delta Virus
Dimitrios Vassilopoulos and Stephanos J. Hadziyannis

8. Diagnosis of Hepatitis D Virus Infection
Jaw-Ching Wu