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DNA Methylation and Cancer Therapy


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Moshe Szyf
McGill University

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-306-47848-2
Pub date: 2004-12-24
239 pages
69 figures
2 color pages

Table of contents

1. DNA Methylation: Three Decades in Search of Function
Aharon Razin

2. Epigenetic Mechanisms of Gene Regulation: Relationships between DNA
Methylation, Histone Modification, and Chromatin Structure
Keith D. Robertson

3. DNA Hypo- vs. Hypermethylation in Cancer: Tumor Specificity, Tumor Progression,
and Therapeutic Implications
Melanie Ehrlich and Guanchao Jiang

4. DNA Methylation in Urological Cancers
Wolfgang A. Schulz and Hans-Helge Seifert

5. DNA Methylation in Colorectal Cancer
Jeremy R. Jass, Vicki L.J. Whitehall, Joanne Young and Barbara A. Leggett

6. CpG Island Hypermethylation of Tumor Suppressor Genes in Human Cancer:
Concepts, Methodologies and Uses
Michel Herranz and Manel Esteller

7. The Loss of Methyl Groups in DNA of Tumor Cells and Tissues:
The Immunochemical Approach
Alain Niveleau, Chandrika Piyathilake, Adriana de Capoa, Claudio Grappelli,
Jean-Marc Dumollard, Lucien Frappart and Emmanuel Drouet

8. Identifying Clinicopathological Association of DNA Hypermethylation
in Cancers Using CpG Island Microarrays
Susan H. Wei, Timothy T.-C. Yip, Chuan-Mu Chen and Tim H.-M. Huang

9. Methylation Analysis in Cancer: (Epi)Genomic Fast Track from Discovery
to Clinical Routine
Carolina Haefliger, Sabine Maier and Alexander Olek

10. Regulation of DNA Methyltransferases in Cancer
Nancy Detich and Moshe Szyf

11. Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation
Anna Reale, Giuseppe Zardo, Maria Malanga, Jordanka Zlatanova and Paola Caiafa

12. The Role of Active Demethylation in Cancer and Its Therapeutic Potential
Moshe Szyf, Paul M. Campbell, Nancy Detich, Jing Ni Ou, Stefan Hamm
and Veronica Bovenzi

13. Purine Analogues and Their Role in Methylation and Cancer Chemotherapy
Katherine L. Seley and Sylvester L. Mosley

14. DNA Methyltransferase Inhibitors: Paving the Way for Epigenetic
Cancer Therapeutics
Gregory K. Reid and A. Robert MacLeod

15. Preclinical and Clinical Studies on 5-Aza-2′-Deoxycytidine,
a Potent Inhibitor of DNA Methylation, in Cancer Therapy
Richard L. Momparler

16. Anticancer Gene Therapy by in Vivo DNA Electrotransfer of MBD2 Antisense
Pascal Bigey and Daniel Scherman