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Molecular Mechanisms of Werner's Syndrome


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Michel Lebel
Université Laval


ISBN: 978-0-306-48233-5
Pub date: 2004-07-27
150 pages


Table of contents

Clinical aspect of Werner syndrome with history, human genetics, cloning and description of mutations in the WRN gene
M. Goto

The role of WRN in DNA repair during the aging process
V. Bohr

Biochemical characteristics of the exonuclease and the RecQ-like helicase functions of WRN

Cellular proteins which interacts with the WRN protein and their effects
T. Enomoto

RecQ in bacteria: What we have learnt from E. coli.
S. Kowalczykowski

RecQ homologues in aging yeast cells: what we have learnt from fission yeast
D. Sinclair

The activity of RecQ-like helicases and topoisomerases
I. Hickson

Werner syndrome homologues in Xenopus and mice
P. Leder

DNA damaging agents and WRN
F. Palitti

Telomeres and Werner syndrome
R. Faragher