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Lynne E. Maquat
University of Rochester
Rochester, New York

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ISBN: 978-1-58706-296-4
Pub date: 2006-02-28
277 pages
65 figures
13 tables
6 color pages

About this book

Nonsense-Mediated mRNA Decay is the first book devoted to nonsense?mediated mRNA decay (NMD). The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of post-transcriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cerevisiae and mammals, from which most NMD data derive. Chapters within these sections discuss the two basic ways cells differentiate between a termination codon that elicits NMD and one that does not. Nonsense-Mediated mRNA Decay makes clear that studies of NMD provide a unique opportunity to examine the coupling of mRNA translation and decay, and relationships between mRNP structure and function. The importance of NMD is evident from descriptions of its influence on the expression of genes that are essential for many cellular processes, including cell differentiation, cell maintenance and cell death. This book is, essentially, meant to be a one-stop source of information that fuels the fires of future experimentation.

Table of contents

SECTION I: SACCHAROMYCES CEREVISIAE

1. Features of Nonsense-Mediated mRNA Decay in Saccharomyces cerevisiae
Kristian E. Baker and Roy Parker

2. All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD
Nadia Amrani and Allan Jacobson

3. Endogenous Substrates of the Yeast NMD Pathway
Feng He and Allan Jacobson

SECTION II: MAMMALS

4. NMD in Mammalian Cells: A History
Lynne E. Maquat

5. Human Upf Proteins in NMD
Guramrit Singh and Jens Lykke-Andersen

6. NMD and the Immune System
Jayanthi P. Gudikote and Miles F. Wilkinson

7. Role of SMG-1-Mediated Phosphorylation of Upf1 in NMD
Akio Yamashita, Isao Kashima and Shigeo Ohno

8. Physiologic Substrates and Functions for Mammalian NMD
Neda A. Sharifi and Harry C. Dietz

9. NMD and Human Disease
Jill A. Holbrook, Gabriele Neu-Yilik, Matthias W. Hentze and Andreas E. Kulozik

10. Therapies of Nonsense-Associated Diseases
Kim M. Keeling, Ming Du and David M. Bedwell

SECTION III: CAENORHABDITIS ELEGANS

11. NMD in Caenorhabditis elegans
Philip Anderson

SECTION IV: DROSOPHILA MELANOGASTER

12. NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway
Isabelle Behm-Ansmant and Elisa Izaurralde

SECTION V: PLANTS

13. NMD in Plants
Ambro van Hoof and Pamela J. Green

SECTION VI: EVOLUTIONARY ASPECTS OF NMD

14. Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
David A.W. Soergel, Liana F. Lareau and Steven E. Brenner

15. NMD and the Evolution of Eukaryotic Gene Structure
Michael Lynch, Xin Hong, and Douglas G. Scofield

SECTION VII: ROLES FOR NMD FACTORS OTHER THAN IN NMD

16. The SMG-1 Kinase: At the Crossroads of mRNA Surveillance and Stress Response Pathways
Robert T. Abraham and Vasco Oliveira

17. Staufen1-Mediated mRNA Decay: A Upf1-Dependent Pathway
Yoon Ki Kim and Lynne E. Maquat

18. Upf1 Regulates Mammalian Histone mRNA Decay
Handan Kaygun and William F. Marzluff

19. S. cerevisiae Est1/H. sapiens SMG6 Protein Family Members Function in Telomere Metabolism
Claus M. Azzalin, Sophie Redon and Joachim Lingner

20. Nonsense-Associated Altered Splicing
Zuo Zhang and Adrian R. Krainer