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Hematopoietic Stem Cell Development


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Isabelle Godin
Institut Gustave Roussy
Villejuif, France

Ana Cumano
Institut Pasteur
Paris, France


ISBN: 978-0-306-47872-7
Pub date: 2006-02-16
178 pages
37 figures


About this book

Hematopoietic Stem Cells brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models. Thus, this book allows a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing the conserved trends in development. This book culminates with state-of –the art knowledge on hematopoietic development in human species and discussions of the most recent breakthroughs with relevance to both researchers and clinicians.

Table of contents

1. Ventral and Dorsal Contributions to Hematopoiesis in Xenopus
Aldo Ciau-Uitz, Maggie Walmsley and Roger Patient

2. Genetic Dissection of Hematopoiesis Using the Zebrafish
Rebecca A. Wingert and Leonard I. Zon

3. Extra- and Intraembryonic HSC Commitment in the Avian Model
Thierry Jaffredo, Karine Bollerot, Krisztina Minko, Rodolphe Gautier, Stéphane Romero
and Cécile Drevon

4. Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem
Cell Differentiation
Jussi Liippo and Olli Lassila

5. Yolk Sac Development in Mice
James Palis

6. Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo
Mervin C. Yoder

7. The Endothelium: The Cradle of Definitive Hematopoiesis?
Katrin Ottersbach and Elaine Dzierzak

8. Endothelial and Hematopoietic Cells in the Intraembryonic Compartment
Fumio Arai and Toshio Suda

9. Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo
Julien Yuan Bertrand, Alexandra Manaia, Jeanne Van Celst, Ana Cumano and Isabelle Godin

10. Hematopoietic Development in Drosophila: A Parallel with Vertebrates
Marie Meister and Shubha Govind

11. Intraembryonic Development of Hematopoietic Stem Cells during Human
Ontogeny: Expression Analysis
Caroline Marshall

12. Gene and Cell Therapy Involving Hematopoietic Stem Cell
Isabelle André-Schmutz and Marina Cavazzana-Calvo