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Sanjay Khare
Amgen Inc.

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ISBN: 978-1-58706-306-0
Pub date: 2007-10-01
100 pages
9 figures
4 tables

About this book

The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate and adaptive immune response, and cellular homeostasis. The chapters of this book address some of the most interesting functions of the TNF/TNFR superfamily.

Table of contents

1. CD40 and CD154
Iqbal S. Grewal

2. Regulation of T Cell Immunity by OX40 and OX40L
Michael Croft, Shahram Salek-Ardakani, Jianxun Song, Takanori So
and Pratima Bansal-Pakala

3. Signal Transduction in Osteoclast Biology: The OPG-RANKL-RANK Pathway
Ji Li

4. Tumor Necrosis Factor (TNF) and Neurodegeneration
Rammohan V. Rao and Dale E. Bredesen

5. The Role of LIGHT in Autoimmunity
Jing Wang and Yang-Xin Fu

6. CD137 Pathway in Innate and Adaptive Immunity
Ryan A. Wilcox and Lieping Chen