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Eric Y. Denkers
Cornell University
Ithaca, New York, U.S.A.

Ricardo T. Gazzinelli
Rene Rachou Research Center - FIOCRUZ
Belo Horizonte, MG, Brazil

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ISBN: 978-1-58706-150-9
Pub date: 2007-06-21
237 pages
35 figures
5 tables
4 color pages

About this book

Using as a theme the encounter between protozoan parasites and macrophages, this volume brings together cell biologists, immunologists and protozoologists to review current developments in this broad and dynamic research area. Discussed are ways protozoans establish their intracellular niche, how they activate macrophage effector functions, what these functions are, and means by which several protozoans subvert macrophage activity. What emerges is a picture of the macrophage as a key cell type in the host response to protozoan infection. How these cells respond, and how their responses can be subverted, are likely to be critical determinants in the outcome of protozoan infection.

Millions of lives are lost every year to protozoan infections, most importantly those caused by Plasmodium, but also Trypanosoma and Leishmania spp. Other protozoans, such as Toxoplasma, are so exquisitely adapted to their host that they rarely cause disease, except during host immunodeficiency. We hope that by working towards an understanding of the biology of protozoans in macrophages we will ultimately be capable of treating and preventing disease and mortality caused by this major class of microbial pathogens.

Table of contents

Introduction: Macrophage Biology
D.M.E. Bowdish and Siamon Gordon

1. Invasion and Intracellular Survival by Toxoplasma
L. David Sibley, Audra Charron, Sebastian Håkansson and Dana Mordue

2. Macrophages, Alternative Niches for Intracellular Growth
of Trypanosoma cruzi
Julio Scharfstein and Marcos André Vannier dos Santos

3. Macrophage — Leishmania Interactions: Complexities
and Uncertainties from the Study of Leishmaniasis in Vivo
Paul M. Kaye

4. Innate Recognition, Cell Signaling and Pro-Inflammatory Response
during Infection with Trypanosoma cruzi
Catherine Ropert and Ricardo T. Gazzinelli

5. Modulation of Positive Signaling and Proinflammatory Responses
by Hemozoin, a Plasmodium Metabolic Waste
Martin Olivier and Maritza Jaramillo

6. Pro-Inflammatory Responses and Cell Signaling during Malaria Infection:
The Parasite Glycosylphosphatidylinositol Ligand
D. Channe Gowda

7. Pro-Inflammatory Responses in Macrophages during Toxoplasma
gondii Infection
Katherine S. Masek and Christopher A. Hunter

8. Down-Modulation of Proinflammatory Signal Transduction
in Toxoplasma gondii-Infected Macrophages
Barbara A. Butcher, Leesun Kim, Chiang W. Lee and Eric Y. Denkers

9. Avoidance of Innate Immune Mechanisms by the Protozoan Parasite,
Leishmania spp
David M. Mosser and Suzanne A. Miles

10. Survival Strategies of Toxoplasma gondii: Interference
with Regulatory and Effector Functions of Macrophages
Carsten G.K. Lüder

11. Targeting SHP-1 to Prevent Macrophage Activation Promotes
Leishmania Pathogenesis
Devki Nandan and Neil E. Reiner

12. Negative Signaling and Modulation of Macrophage Function
in Trypanosoma cruzi Infection
Flávia L. Ribeiro-Gomes, Marcela F. Lopes and George A. DosReis

13. Effector Functions of Macrophages in Plasmodium Parasite Infections
Mariela Segura, Rebecca Ing, Zhong Su, Neeta Thawani and Mary M. Stevenson

14. Innate Control of Toxoplasma gondii through Macrophage-Based
Effector Mechanisms
Gregory A. Taylor

15. Phagocyte Effector Functions against Leishmania Parasites
Christian Bogdan

16. Effector Mechanisms of Macrophages Infected with Trypanosoma cruzi
Fredy R.S. Gutierrez, Flavia S. Mariano, Isabel K.F. Miranda-Santos Bogdan
and João S Silva