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Lluis Ribas de Pouplana
Scripps Research Institute

Table of contents

Foreword
Alex Rich

The Genetic Code and the tree of Life
Jim Brown

The nature of the last common ancestor
Antonio Lazcano

The early earth environments
Oliver Botta and Jeff Bada

The chemical precursors to nucleic acids
Jeffrey Zubay

Early chemical catalysis
Gustaf Arrhenius

RNA molecules as general catalysts
Don Burke

RNA molecules as precursors of the genetic code functions and relationships
Mike Yarus Rob Knight

Self replicating macromolecules
Reza Ghadiri Julius Rebek

Origin and evolution of the ribosome
George Fox

The tRNA molecule
Peggy Saks

Aminoacyl-tRNA synthetases
Lluis de Pouplana Paul Schimmel

Elongation factors
Mathias Sprinzl

Evolution of genome replication mechanisms
Patrick Forterre HannuMyllykallio

Evolution of DNA repair mechanisms
Jocelyn DiRuggiero Frank Robb

Selective forces behind the evolution of the genetic code
Rob Knight Laura Landweber

Natural Genetic code variants
Micke Tuite Manuel Santos

New codes altogether
David Liu