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Telomerases, Telomeres and Cancer


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Guido Krupp
artus Gmbh

Reza Parwaresch
Christian-Albrechts-Universität zu Kiel

This book is co-published with Springer.

Please click here to purchase this book at the Springer site.

ISBN: 978-0-306-47437-8
Pub date: 2002-12-01
426 pages
116 figures
18 tables

Table of contents

SECTION I: TELOMERASES, TELOMERES AND CANCER

SECTION IA: TELOMERASE ACTIVITY AND CANCER

1. The Significance of Quantitative Evaluation of Telomerase Activity
and hTERT mRNA Expression in Colorectal Cancers
Melissa Poggesi, Stefania Gelmini, Claudia Casini Raggi, Fabio Cianchi,
Rosa Valanzano, Mario Pazzagli and Claudio Orlando

2. The Role of Telomerase De-Regulation in Keratinocyte Immortality
and the Progression of Human Head and Neck Cancer
E. Kenneth Parkinson

3. Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications
Karl Dhaene

4. Telomerase Activity in Mesenchymal Tumors
Regine Schneider-Stock, Carsten Boltze, and Albert Roessner

5. Telomerase Activity in Neuroblastomas: A New Molecular Marker
for Treatment Stratification and Prognostic Grouping
Christopher Poremba and Barbara Dockhorn-Dworniczak

6. Telomerase and Radiosensitivity of Human Tumors
Tej K. Pandita

7. Amplification of hTERT, the Telomerase Reverse Transcriptase
Gene in Human Cancers
Dawei Xu, Anju Zhang, Mi Hou, Magnus Björkholm and Astrid Gruber

8. Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate
Sensitivity of Neoplastic Cells to Cancer Treatment
Isabella Faraoni and Enzo Bonmassar

SECTION IB: TELOMERASE-BASED APPROACHES
FOR CANCER THERAPIES

9. PNA and Oligonucleotide Inhibitors of Human Telomerase
Gérald Gavory and Shankar Balasubramanian

10. Potential of the Telomerase Catalytic Subunit as a Universal
Tumor-Associated Antigen for Cancer Immunotherapy
Robert H. Vonderheide and William C. Hahn

SECTION II: STRUCTURE AND FUNCTION OF TELOMERASES
AND TELOMERES

SECTION IIA: HUMANS

11. The Makings of Telomerases
Joachim Lingner and Christian Wenz

12. Regulation of Telomerase Activity
Jun-Ping Liu, Siddhartha Deb, and He Li

13. Telomeres and Mechanisms of DNA Double Strand Break Repair
Predrag Slijepcevic

14. Roles for hTERT and Telomerase in Cell Differentiation and Apoptosis
Mark P. Mattson, Peisu Zhang, Weiming Fu

SECTION IIB: CILIATES, YEASTS AND OTHER EUKARYOTES

15. Human, Mouse and Yeast Telomerase
Tara J. Moriarty and Chantal Autexier

16. The Biology of Telomeres in Hypotrichous Ciliates
Franziska Jönsson and Hans J. Lipps

17. DNA Primer Extension by Telomerase
Haim Manor, Yonit Haviv and Nava Baran

18. Yeast Telomerases: Structure, Mechanisms and Regulation
Neal F. Lue

19. RAP1 Binding and Length Regulation of Yeast Telomeres
Johan Wahlin and Marita Cohn

20. Linear Plasmids in Yeasts and Filamentous Fungi
Livia Civitelli and Fiorentina Ascenzioni

21. New Telomere Formation During the Process of Chromatin Diminution
in the Parasitic Nematodes Ascaris suum and Parascaris univalens
Fritz Müller

22. Telomerase Activity in Sponges (Porifera), the Closest Related Taxa
of the Hypothetical Ancestral Animal the Urmetazoa
Werner E.G. Müller

23. Structure and Maintenance of Chromosome Ends in Plants
Jîrí Fajkus and Ulrike Zentgraf

SECTION III: MAINTAINING TELOMERES WITHOUT TELOMERASE

24. Telomeres without Telomerase in Saccharomyces cerevisiae
Edward J. Louis

25. Recombinational Telomere Elongation in the Yeast Kluyveromyces lactis
Michael J. McEachern

26. Telomere Maintenance in Human Cell Lines and Tumors without Telomerase
Clare L. Fasching, Roger R. Reddel

SECTION IV: NON-CLASSICAL TELOMERE STRUCTURES

27. Telomeres in Drosophila and Other Insects
Harald Biessmann, Marika F. Walter and James M. Mason

28. Mitochondrial Telomeres: Alternative Solutions to the End-Replication
Problem
Jozef Nosek and Lubomir Tomaska