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Reactivation of the Cell Cycle in Terminally Differentiated Cells


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Marco Crescenzi
Istituto Superiore di Sanita


ISBN: 978-0-306-47423-1
Pub date: 2003-01-25
102 pages
39 figures
4 tables


About this book

Terminal differentiation is defined as the state in which a cell has acquired specialized properties and has ceased proliferating permanently. This book comprehensively describes whether the terminally differentiated state actually exists, the molecular mechanisms that control the post-mitotic state, and whether terminally differentiated cells can be induced to proliferate in a stable, controllable and reversible fashion.

Table of contents

Reactivation of Terminally Differentiated Cells: Introduction
Marco Crescenzi

Cell cycle reactivation in skeletal musce cells
Marco Crescenzi

Myocyte Proliferation in the Failing Heart
Piero Anversa

Reversal of terminally differentiated state in skeletal myocytes by SV40 large T antigen
Takeshi Endo

Regulation of proliferation and apoptosis in the cardiac myocyte
Loren J. Field

The \"Post-mitotic\" Phenotype in Cardiac Muscle Cells
Michael D. Schneider

Cellular de-differentiation during regeneration: the amphibian muscle system
Elly M. Tanaka