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Michael Ibba
Ohio State University

Christopher Francklyn
University of Vermont

Stephen Cusack
European Molecular Biology Laboratory

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ISBN: 978-1-58706-189-9
Pub date: 2005-04-01
437 pages
234 figures
37 tables
43 color pages

About this book

By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.

Table of contents

1. The World of Aminoacyl-tRNA Synthetases
Paul Schimmel and Dieter Söll

2. Arginyl-tRNA Synthetases
Gilbert Eriani and Jean Cavarelli

3. Cysteinyl-tRNA Synthetases
Ya-Ming Hou and John J. Perona

4. Isoleucyl-tRNA Synthetases
Brian E. Nordin and Paul Schimmel

5. Leucyl-tRNA Synthetases
Tommie L. Lincecum, Jr. and Susan A. Martinis

7. Valyl-tRNA Synthetases
Osamu Nureki and Shigeyuki Yokoyama

8. Class I Lysyl-tRNA Synthetases
Alexandre Ambrogelly, Dieter Söll, Osamu Nureki, Shigeyuki Yokoyama
and Michael Ibba

9. Glutaminyl-tRNA Synthetases
John J. Perona

10. Glutamyl-tRNA Synthetases
Daniel Y. Dubois, Jacques Lapointe and Shun-ichi Sekine

11. Trytophanyl-tRNA Synthetases
Charles W. Carter

12. Tyrosyl-tRNA Synthetases
Hugues Bedouelle

14. Histidyl-tRNA Synthetases
Christopher Francklyn and John Arnez

15. Prolyl-tRNA Synthetases
Karin Musier-Forsyth, Brian Burke and Stephen Cusack

16. Threonyl-tRNA Synthetases
Anne-Catherine Dock-Bregeon, Pascale Romby and Mathias Springer

17. Seryl-tRNA Synthetases
Ivana Weygand-Durasevic and Stephen Cusack

18. Asparaginyl-tRNA Synthetases
Daniel Kern, Hervé Roy and Hubert Dominique Becker

19. Aspartyl-tRNA Synthetases
Richard Giegé and Bernard Rees

20. Class II Lysyl-tRNA Synthetases
Sylvain Blanquet, Pierre Plateau and Silvia Onesti

21. Alanyl-tRNA Synthetases
Lluis Ribas de Pouplana, Karin Musier-Forsyth and Paul Schimmel

22. Phenylalanyl-tRNA Synthetases
Mark Safro, Nina Moor and Olga Lavrik

23. tRNA Aminoacylation: The Crucial Roles of tRNA Deformability and Backbone-
Mediated Interactions by Synthetase
William H. McClain

24. Mitochondrial Aminoacyl-tRNA Synthetases
Marie Sissler, Joern Pütz, Franco Fasiolo and Catherine Florentz

26. Multi-Aminaocyl-tRNA Complexes
Marc Mirande

27. Regulation of Aminoacyl-tRNA Synthetase Gene Expression in Bacteria
Tina M. Henkin

28. Transfer RNA-Dependent Amido-transferases: Key Enzymes for Asn-tRNA
and Gln-tRNA Synthesis in Nature
Liang Feng, Debra Tumbula-Hansen, Bokkee Min, Suk Namgoong, Juan Salazar,
Omar Orellana, and Dieter Söll

32. Ribozyme-Catalyzed tRNA Aminoacylation
Hiroaki Suga, Hirohide Saito and David R.W. Hodgson

33. Protein Tagging and Ribosome Rescue in Bacteria Requires the Recognition
of Transfer-Messenger RNA by an Aminoacyl-tRNA Synthetase
Brice Felden, Reynald Gillet, Laurent Metzinger

34. Accuracy of Aminoacyl-tRNA Synthetases: Proofreading of Amino Acids
Hieronim Jakubowski

35. Aminoacyl-tRNA Synthetases and Disease
Michael Kron and Michael Härtlein

36. Aminoacyl-tRNA Synthetases As Anti-Infective Drug Targets
John Finn and Jianshi Tao