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Molecular Mechanisms of Disseminated Intravascular Coagulation


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Hugo ten Cate
Academic Medical Centre Amsterdam

Marcel Levi
Academic Medical Centre Amsterdam

List price: $149.00
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ISBN: 978-1-58706-058-8
Pub date: 2003-07-09
226 pages


Table of contents

Concept of DIC:definition, clinical relevance, pathogenesis
Hugo ten Cate and Marcel Levi

Regulation of tissue factor expression
Wolfram Ruf

Blood borne tissue factor (including microparticles)
Bjarne Osterud

Tissue factor and its pleiotropic effects
Henri Versteeg and Arnold Spek

Contributions of the plasma kallikrein/ kinin system
Alvin Schmaier

Factor XI, TAFI and DIC
Monique Minnema, Joost Meijers

Cytokines as regulators of coagulation and fibrinolysis
Tom van der Poll

Fibrinolysis and its relevance for organ failure

The regulatory function of the thrombomodulin-protein C system
K. Okajima

Endothelial perturbation
Nicola Semeraro and Mario Collucci

Disease specific initiators
Hanneke Kremer, Hans Martin Otten and Hugo ten Cate

Thrombotic microangiopathies
Bernard Lammle

Genetic risk factors
Dirkje Sommeijer, Pieter Reitsma

Is DIC a proinflammatory syndrome?
Eric Hack

Is DIC a clotting disorder?
Marcel Levi

Options for molecular, therapeutic intervention
Marcel Levi, Philip Friederich and Hugo ten Cate