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Hildegund Ertl
Wistar Institute

About this book

DNA vaccines, first described less than 10 years ago, have shown efficacy in experimental animals against a number of afflictions caused by infectious agents, cancer or misguided immunological responses. Results obtained in clinical trials have been disappointing thus far. The ‘DNA Vaccine’ book details in the initial chapters the immunological mechanisms that govern immune responses to vector encoded antigens. The remaining chapters illustrate the use of DNA vaccines for prevention or therapy of infectious diseases, cancer, autoimmune reactions, allergies and rejection of proteins delivered within the realm of gene therapy.

Table of contents

1. Overview of Vaccinology in Historic and Future Perspective:
The Whence and Whither of a Dynamic Science with Complex Dimensions
Maurice R. Hilleman

2. Dendritic Cells: Important Adjuvants During DNA Vaccination
Ralph M. Steinman, Constantin Bona and Kayo Inaba

3. Activation of the Innate Immune System by DNA Vaccines
Julie Fitzgerald and Hildegund C. J. Ertl

4. Induction of B Cells by DNA Vaccines
K. Kilpatrick, M. Sarzotti and G. Kelsoe

5. Immune Responses to DNA Vaccines: Induction of CD8+ T Cells
Jens A. Leifert and J. Lindsay Whitton

6. Minigene-Based Vaccines for Eliciting CD8+ T Cell Responses
Jonathan W. Yewdell

7. DNA Vaccines Against RNA Viruses
Jeffrey B. Ulmer

8. DNA Vaccines Against Herpesviruses
Christopher Pack and Barry T. Rouse

9. Genetic Immunization Against HIV
Britta Wahren, Karl Ljungberg, Anne Kjerrström Zuber and Bartek Zuber

10. DNA Vaccines Against Bacterial Pathogens
M. A. Chambers, H. M.Vordermeier, R. G. Hewinson and D.B. Lowrie

11. DNA Vaccines as Cancer Treatment Modalities
Ronald C. Kennedy, Michael H. Shearer and Robert K. Bright

12. DNA Vaccines for Allergic Diseases
Kaw Yan Chua, Betina Wolfowicz and Patrick G. Holt

13. Immune Responses in Gene Transfer for Genetic Disorders
Denise E. Sabatino and Katherine A. High

14. The Use of DNA Vaccines for Neonatal/Early Life Childhood Immunization
Jiri Kovarik, Xavier Martinez and Claire-Anne Siegrist

15. DNA Delivery with Attenuated Intracellular Bacteria
Joachim Fensterle and Stefan H. E. Kaufmann

16. Cytokines and Immunomodulatory Ligands as Genetic Adjuvants
Hildegund C. J. Ertl

17. Chemokines: Role as Immunomodulators and Potential as Adjuvants
for DNA Vaccines
Philip M. Murphy

18. DNA Vaccines: Safety and Regulatory Issues
Dennis M. Klinman and Herbert A. Smith

19. The Introduction of New DNA Vaccines into Developing Countries
Richard T. Mahoney, Yu-Mei Wen, Henry Wilde and Zhi-Yi Xu