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The Artificial Kidney: Physiological Modeling and Tissue Engineering


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John K. Leypoldt
University of Utah

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ISBN: 978-1-57059-602-5
Pub date: 1999-10-01
116 pages
46 figures
3 tables


About this book

Fundamental engineering principles are essential to consider when designing and developing artificial organs, especially the artificial kidney. Early contributors to the development of the artificial kidney were primarily chemical and electrical engineers who developed improved hemodialysis membranes, methods for producing large quantities of dialysis solutions and easy-to-use machines or dialysis delivery systems. Efforts along these lines continue today to improve hemodialysis and peritoneal dialysis therapies. Recent engineering efforts to improve artificial kidney therapies have focussed on developing a better understanding of the effect of hemodialysis and peritoneal dialysis on patient physiology or pathophysiology, and develop improved treatments using recent advances in tissue, cellular and genetic engineering. Investigators active in these areas have contributed authoritative chapters to this book. The focus of this book is to provide bioengineers and other interested researchers with comprehensive reviews of active research related to the artificial kidney. Each chapter begins from first principles and develops the topic to include the most recent research.from authors who are experts in their respective fields. This approach will permit both the student and the expert to gain a thorough understanding of this research area.

Table of contents

Fluid Removal During Hemodialysis
John K. Leypoldt and Alfred K. Cheung

Urea Removal During Hemodialysis
Daniel Schneditz

Transport Kinetics During Peritoneal Dialysis
Michael F. Flessner

The Bioartificial Renal Tubule
H. David Humes, Sherrill MacKay and Janeta Nikolovski

Percutaneous Access for Peritoneal Dialysis: A Tissue Engineering Approach
Jennifer A. LaIuppa, Cliff J. Holmes

Tissue Engineering in the Peritoneal Cavity: Genetic Modification of the Peritoneal Membrane
Catherine M. Hoff, Ty R. Shockley