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Tissue Engineering of Vascular Prosthetic Grafts


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Peter Zilla
University of Cape Town
Cape Town, South Aftica

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ISBN: 978-1-57059-549-3
Pub date: 1999-10-01
621 pages
323 figures
35 tables


About this book

This book is about the perfect vascular graft: A hypothetical discussion of what it is and how one may go about producing it.. By exploring some basic biological areas and introducing the background of clinical and pathological failures and demands, this book shall serve as a comprehensive guide, furthering the research initiatives of academic vascular surgeons, scientists and industry researchers.

Table of contents

1. The Lack of Healing in Conventional Vascular Grafts
L. Davis, T. Dower, P. Zilla

2. Noncompliance: The Silent Acceptance of a Villain
A.M. Seifalian, A. Giudiceandrea, T. Schmitz-Rixen,
G. Hamilton

3. Endothelial Cell Seeding: A Review
S. Schmidt, G. L. Bowlin

4. Surface Precoating in the 1980s: A First Taste of Cell-Matrix Interactions
M. G. Walker, J. V. Smyth

5. Surface Precoating in the 1990s: The Fine Tuning of Endothelial Cell Transplantaion
M.M. Samet, V.V. Nikolaychik, P. I. Lelkes

6. Microvascular Endothelial Cell Transplantation: A Review
S. K. Williams

7. Morphological Aspects of Microvascular Cell Isolates
M. Vici

8. Functional Aspects of Microvascular Cell Isolates
M. Fittkau, T. Fischlein

9. Automated Seeding Device
D. Dodd, J.V. Smyth, M. Walker

10. Healing Patterns Following Microvascular Cell Seeding -A Clinical Evaluation of Microvascular-Seeded A-V Access Grafs
S. Schmidt, S.O. Meerbaum, D.L. Donovan

11. Neointimal Hyperplasia in Small-Diameter Prosthetic Vascular Grafts: Influence of Endothelial Cell Seeding with Microvascular Omental Cells in a Canine Model
M. Pasic, W. Müller-Glauser, M. Turina

12. Human Clinical Trials of Microvascular Endothelial Cell Sodding
S. K. Williams

13. In Vitro Endothelialization: Its Contribution Towards an Ideal Vascular Replacement
P. Zilla

14. Serial Cultivation of Human Endothelial Cells
C. Gillis-Haegerstrand, A. Haegerstrand

15. Risk Factors for Autologous Endothelial Cell Cultures
J.G. Meinhart, M. Deutsch, P. Zilla

16. Adhesion Molecule Expression Following In Vitro Lining
C. Gillis-Haegerstrand

17. In Vitro Endothelialization Elicits Tissue Remodelling Emulating Native Artery Structures
M. Deutsch, J. Meinhart, P. Zilla

18. In Vitro Endothelialization of Synthetic Vascular Grafts in Long Term Clinical Use
M. Deutsch, J. Meinhart, T. Fischlein, P. Zilla

19. Inflammatory Reaction: The Nemesis of Implants
J. Anderson

20. Molecular Determinants of Acute Inflammatory Responses to Biomaterials
L. Tang, J. W. Eton

21. The Accumulation of Inflammatory Mediators: A Target for the Prevention of Fibrosis
S. Wahl, J. Zagorski

22. Pathobiology of Hyperplastic Intimal Responses
E. L. Owens, A. Clowes

23. Cell Cycle Interruption to Inhibit Neointimal Hyperplasia Facilitation of Healing
M.J. Mann, R.C. Braun-Dollaeus, V. Dzau

24. Signaling Mechanisms for Vascular Cell Migration
I. Zachary

25. Adhesion Molecules: Potent Inducers of Endothelial Cell Chemotaxis
A. Koch, Z. Szekanecz

26. Angiogenesis in Tissues and Vascular Grafts
P. K. Shireman, H. P. Greisler

27. Polypeptide Growth Factors with a Collagen Binding Domain: Their Potential for Tissue Repair and Organ Regeneration
M. Nimni, B. Han, L.L.H. Huang, D. Cheung, F. Cordoba

28. Fibroblast Growth Factors in Angiogenesis and Tissue Engineering
K. Blumofe, T.J. Heilizer, P.K. Shireman, H.P. Greisler

29. Role of Urokinase-Type Plasminogen Activator (u-PA) in In Vitro Angiogenesis in Fibrin Matrices
P. Koolwijk, V. W.M. van Hinsbergh

30. How Does Extracellular Matrix Control Capillary Morphogenesis?
R. B. Vernon, E. H. Sage

31. Collagen Matrices Attenuate Fibroblast Response to TGF-b
R. A.F. Clark, J.M. McPherson

32. Extracellular Matrix Proteins are Potent Agonists of Human Smooth Muscle Migration
T. L. Kaiura, K. C. Kent

33. Extracellular Matrix Effect on Endothelial Control of Smooth Muscle Cell Migration and Matrix Synthesis
R. J. Powell

34. Circulating Stem Cells: A Fourth Source for the Endothelialization of Cardiovasculr Implants
W. Koen

35. Surface Population with Blood-Borne Cells
W.P. Hammond

36. Cellular Population of the Textured-Surface Left Ventricular Assist Devices Leads to Sustained Activation of a Procoagulant and Proinflammatory Systemic Response
T. B. Spanier, A.M. Schmidt, M. C. Oz

37. Transdifferentiation and the Vascular Wall
W. A. Beresford

38. Endothelial Cells Transformed from Fibroblasts During Angiogenesis
T. Fujiwara, K. Kon

39. Mechanical Forces and Cell Differentiation
I. Mills, B.E. Sumpio

40. An Integral Mathematical Apporach to Tissue Engineering of Vascular Grafts
G.R. Starke, A.S. D. D.J. Conway

41. Bioinertness: An Outdated Principle
D. Williams

42. Bioinert Materials: Are Their Properties Irreplaceable?
P. T. Cahalan

43. Biostable Polymers as Durable Scaffolds for Tissue Engineered Vascular Prostheses
A.J. Coury

44. Biophilic Polymers: What\\\'s on the Horizon?
P. Cahalan

45. Bioresorblable Grafts: A Counterintuitive Approach
D. Fox, D. A. Vorp, H. Greisler

46. Biodegradable Materials
K.J.L. Burg, S.W. Shalaby

47. The Influence of Porosity and Surface Roughness on Biocompatibility
J.M. Schakenraad, K.H. Lam

48. Microgroove Driven Tissue Ingrowth
E.T. D. Braber, J. A. Janseen

49. Surface Bonding of Heparin
P. Cahalan

50. Covalent Grafting of RGD Peptides to Synthetic Surfaces
N.M.K. Lamba, S.L. Cooper

51. Hydrogels in Biological Control During Graft Healing
J. A. Hubbell

52. In Vivo Synthesis of Organs Using Collagen-GAG Copolymers
I.V. Yannas

53. Artificial Extracellular Matrix Proteins for Graft Design
A. Panitch, D. A. Tirrell

54. Cell-Extracellular Matrix Interactions Relevant to Vascular Tissue Engineering
S.P. Massia

55. Use of Hydroxypropylchitosan Acetate as a Carrier for Growth Factor Release
K. Yamamura, T. Nabeshima, T. Sakurai

56. Transplantation of Transduced Smooth Muscle Cells: A Vehicle for Local and Systemic Gene Therapy
R. L. Geary, A. W. Clowes, M. M. Clowes