Adenoviruses: Basic Biology to Gene Therapy
Email this
Print this
Prem Seth
This book is out of print, hard copy not available. |
|
About this bookEver since their discovery, adenoviruses have proven to be a tremendous asset to biologists. Through the study of the adenoviruses the authors have learned not only about the virus structures, mechanisms of viral replication, but also about eukaryotic gene expression, alternative splicing, regulation of cell cycle progression, and apoptosis. In the last five years, there has been an explosion in the use of adenoviruses as vectors for gene transfer to a variety of mammalian cells. Adenoviral vectors are also being tested in Phase 1 clinical trials for cystic fibrosis and for many kinds of cancers. These recent developments in utilizing adenoviral vectors for gene therapy have rejuvenated an interest in the basic science of adenovirus research. More importantly, it has generated a necessity for a single volume that covers both the biology of adenoviruses as well as our progress in the use of adenoviruses as vectors for gene therapy. This book was written precisely to fulfill such a need. |
|
Table of contentsDiscovery and Classification of Adenoviruses Adenovirus Capsid Proteins Organization of the Adenoviral Genome Entry of Adenovirus into Cells Early Gene Expression Adenovirus DNA Replication Adenovirus Late Gene Expression Role of Endoprotease in Adenovirus Infection Adenovirus Assembly Development of Adenoviral Vectors for Gene Therapy Adenoviral Vectors for Cancer Gene Therapy Adenoviral Vectors for Cardiovascular Diseases IAP-Based Gene Therapy for Neurodegenerative Disorders Adenovirus Vectors for Therapeutic Gene Transfer to Skeletal Muscles Adenovirus-Mediated Gene Transfer: Applications in Lipoprotein Research Correction of Serum Protein Deficiencies with Recombinant Adenoviral Vectors Adenoviral Vectors for Vaccines Strategies to Adapt Adenoviral Vectors for Gene Therapy Applications Adenovirus-AAV Combination Strategies for Gene Therapy Transcriptional and Promoter-Driven Control of Adenovirus-Mediated Gene Expression Development of an E1B, 55 kDa Gene-deleted, Selectively Replicating Adenovirus for the Treatment of Cancer: ONYX-015 Adenoviral Vectors for the Manipulation of Human Hematolymphoid Cells: Purging and Other Applications Adenovirus Transformation and Tumorigenicity Homologous Recombination Between Exogenous and Integrated Adenovirus DNA Sequences Adenovirus-Induced Pathogenesis Adenovirus-Host Interactions to Subvert the Host Immune System Implications of the Innate Immune System for Adenovirus-Mediated Gene Transfer Host Immune Responses to Recombinant Adenoviral Vectors AdCFTR for Cystic Fibrosis Ad-p53 Clinical Trial in Patients with Squamous Cell Carcinoma of the Head and Neck Adenoviral Vectors for Liver Cancer Clinical Trials Opportunities for p53 Tumor Suppressor Gene Therapy in Ovarian and Other Peritoneal Cancers Adenoviral Gene Therapy for Malignant Pleural Mesothelioma |
|