Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications
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Shaker A. Mousa
This book is out of print, hard copy not available. |
About this bookThe regulation of blood vessel growth underlies many normal biological processes such as reproduction, development, repair and wound healing. It also is a critical feature of pathological processes such as cancer, diabetic retinopathy, macular degeneration, inflammatory arthritis and ischemic heart disease. What causes blood vessels to grow? What inhibits their growth? This book comprehensively describes the angiogenic proteins that enhance and inhibit normal and abnormal angiogenesis. It describes the potential therapeutic applications of basic fibroblast growth factor, vascular endothelial growth factor, PECAM-1 and thrombospondin as well as other factors. The book brings together information about new blood vessel formation in many organ systems and comprises an outstanding resource on the state-of-the art in angiogenesis. |
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Table of contentsMechanisms of Angiogenesis: Potential Therapeutic Targets Angiogenesis and Ischemia: The Effect of SIKVAV and NPY in Revascularization The Role of Smooth Muscle Cells and Pericytes in Angiogenesis Integrins av in Health and Disease Role of avb3 in Metastasis, Vascular Remodeling and Angiogenesis PECAM-1 and Angiogenesis Thrombospondin and Angiogenesis The Role of Vascular Endothelial Growth Factor in Angiogenesis Regulation of Angiogenesis by Fibroblast Growth Factors Role of Angiogenesis in Wound Healing Ocular Neovascularization Anti-Angiogenesis Strategies: Potential Therapeutic Implications Matrix Metalloproteinase Inhibitors in Angiogenesis Mediated Disorders with Special Emphasis on Cancer Pharmaceutical Development of an Antiangiogenic Drug-Candidate: Challenges and Opportunities Surrogate Endpoints as a Measure of Efficacy in Clinical Trials of Angiogenesis Inhibitors Lessons from Clinical Trials of Anti-Angiogenic Drugs in the Treatment of Cancer |
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