Molecular Basis of Epithelial Appendage Morphogenesis
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Cheng-Ming Chuong
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About this bookEpithelial appendages are the derivatives of the epithelial sheet. On the body surface, they include hair, feathers, scales, claws, horns, sebaceous glands, mammary glands, etc. In the oral cavity, they include teeth, salivary glands, etc. Inside the body, the surfaces of the gut are covered with different derivatives that line the stomach, small intestine, colon, etc. Lung, pancreas and liver begin as epithelial derivatives of the endodermal tube. These organs are diverse in structure and function. However, is there a common theme underlying their formation?This book identifies simple principles underlying the seemingly diverse phenomena of organ formation. Data accumulated so far suggest that most of the molecular mechanisms are shared in different organogenetic processes, in body axis construction, and even have their roots in Drosophila morphogenesis. The new unifying concept is a pleasure to appreciate. Each chapter provides the most up-to date information written by leaders in the field. |
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Table of contentsPart I: Overview Morphogenesis of Epithelial Appendages: variations
on Top of a Common Theme and Implications in Regeneration Ectodermal Dysplasia: A Synthesis Between Evolutionary,
Developmental, and Molecular Biology and Human Clinical Genetics Why Study Hair Follicles? A Personal Account
Part II: Morphogenesis of Epithelial Appendages on the Body Surface Variations of Cutaneous Appendages: Regional Specification
and Cross-Species Signals Feather Morphogenesis: A Model of the Formation of
Epithelial Appendages Principles of Hair Follicle Morphogenesis Epithelial-Mesenchymal Interactions in Gastrointestinal
Development Growth of the Hair Follicle: A Cycling and Regenerating
Biological System Development of Melanocytes from Neural Crest Progenitors
Part III: Morphogenesis of Epithelial Appendages Within the Body The Teeth as Models for Studies on the Molecular Basis
of the Development and Evolution of Organs Epithelial-Mesenchymal Interactions in Gastrointestinal
Development Endodermal Appendage Formation: Morphogenetic Mapping
of Dorso-Ventral Patterning of the Anterior Foregut and Development of Lung
and Thyroid Primordia Lung Epithelial Morphogenesis: Integrated Functions
of Transcriptional Factors, Peptide Growth Factors, Extracellular Matrix, Physiological
and Environmental Factors Part IV: Molecular Mechanism Early Molecular Events in Feather Morphogenesis: Induction
and Dermal Condensation Signaling Loops in the Reciprocal Epithelial-Mesenchymal
Interactions of Mammalian Tooth Development Topobiology of the Hair Follicle: Adhesion Molecules
as Morphoregulatory Signals During Hair Follicle Morphogenesis Late Events and the Regulation of Keratinocyte Differentiation
in Hair and Feather Follicles Part V: ModelsEpithelial
Morphogenesis: A Physico-Evolutionary Interpretation Periodic Pattern Formation of the Feathers Gene Networks and Supernetworks: Evolutionary Conserved
Gene Interactions Part VI: Approaches Current Methods in the Study of Avian Skin Appendages
Molecular Biology of Anhidrotic Ectodermal Dysplasia
Systematic Approach to Evaluation of Mouse Mutations
with Cutaneous Appendage Defects |
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