Proteasomes: The World of Regulatory Proteolysis
|
Email this
Print this
Wolfgang Hilt
Dieter H. Wolf
List price: $169.00 |
About this bookThis book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation. The surprise was even greater when it was found that not lysosomes, but protease complexes with remarkably sophisticated architectures were responsible for the control of essential regulatory events. Excitingly, proteasomes were found to be involved in widespread functions of cell physiology, which included degradation of protein waste, antigen presentation, regulation of cell metabolism and cell differentiation as well as control of the cell cycle. The discovery of such multiple and essential functions made investigation of proteasome mediated regulatory proteolysis a highly significant theme in cell biology. Written by pioneers in the field the book represents a comprehensive up-to-date view on proteasome structures and functions from the ultimate frontier of cell biology research. It ties the reader to all facets of cell function. This work is an indispensable source for scientists working in the fields of basic and applied cell biology and immunology. Different aspects of proteasome functions are associated with the development of detrimental diseases like cancer, neurodegeneration, cystic fibrosis or immune disorders. Therefore, data reviewed in this book are important for physicians and pharmacologists active in research, and experts in the pharmaceutical industry. |
|
Table of contentsProteasomes: A Historical Retrospective Proteasomes in Prokaryotes Proteasome Crystal Structures Subunit Arrangement in the Human
Proteasome Active Sites and Assembly of
the 20S Proteasome The Regulatory Particle of the
Yeast Proteasome The Mammalian Regulatory Complex
of the 26 S Proteasome The 20S Proteasome Activator PA28
or 11S Regulator Proteasome Activators and Synthetic
Modulators: Significance for Antigen Presentation The Proteasome Inhibitors and
Their Uses Intracellular Localization of
Proteasomes Primary Destruction Signals The Ubiquitin System in Yeast The Ubiquitin-Proteasome Pathway
in Mammals: Mechanisms of Action and Deubiquitinating Enzymes and the
Regulation of Proteolysis Degradation of Ornithine Decarboxylase,
a Ubiquitin-Independent Proteasomal The Ubiquitin-Proteasome System
in Cell Cycle Control p53 and the Proteasome Pathway The Role of the Proteasome in
Apoptosis Function of the Proteasome in
the Protein Quality Control Process of the Endoplasmic Reticulum MHC Class I Antigen Presentation
and the Proteasome Pathway Ubiquitin, Proteasomes and Neurodegenerative
Disease The Proteasome in Posttranscriptional
Control: A Protease with Endonuclease Activity? |
|