Lysosomes
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Paul Saftig
This book is co-published with Springer.
Please click here to purchase this book at the Springer site. ISBN: 978-0-387-25562-0 Pub date: 2005-07-07 209 pages 59 figures 1 color pages |
About this bookLysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing. |
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Table of contents1. History and Morphology of the Lysosome 2. Transport of Lysosomal Enzymes 3. Adaptor Proteins in Lysosomal Biogenesis 4. Lysosomal Membrane Proteins 5. Lysosomal Proteases: Revival of the Sleeping Beauty 6. Lysosomal Storage Disorders 7. Lysosomal Transporters and Associated Diseases 8. Neuronal Ceroid-Lipofuscinoses 9. Cholesterol Transport in Lysosomes 10. Therapy of Lysosomal Storage Diseases 11. Lysosomal Proteome and Transcriptome 12. External Lysosomes: The Osteoclast and Its Unique Capacities to Degrade
Mineralised Tissues 13. Membrane Resealing Mediated by Lysosomal Exocytosis 14. Macroautophagy in Mammalian Cells 15. Chaperone-Mediated Autophagy |
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