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Harald Wajant
University of Wuerzburg
Wuerzburg, Germany

About this book

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well-recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for anyone with an interest in the biology of this exciting molecule.

Table of contents

1. FasL and Fas: Typical Members of the TNF Ligand and Receptor Family
Anja Krippner-Heidenreich and Peter Scheurich

2. FasL-Independent Activation of Fas
Faustino Mollinedo and Consuelo Gajate

3. Role of Ceramide in CD95 Signaling
Volker Teichgräber, Gabriele Hessler and Erich Gulbins

4. Regulation of Fas Signaling by FLIP Proteins
Margot Thome

5. Fas-Induced Necrosis
Tom Vanden Berghe, Nele Festjens, Michael Kalai, Xavier Saelens and Peter Vandenabeele

6. Fas–More Than an Apoptosis Inducer
Harald Wajant

7. Retrograde Fas Ligand Signaling
Andreas Linkermann, Jing Qian and Ottmar Janssen

8. FasL and Fas in Liver Homeostasis and Hepatic Injuries
Maria Eugenia Guicciardi and Gregory J. Gores

9. Fas-Activation, Development and Homeostasis of T Cells
Georg Häcker

10. The FasL-Fas System in Disease and Therapy
Harald Wajant and Frank Henkler

11. Tools for Activation and Neutralization of Fas Signaling
Pascal Schneider