Planaria: A Model for Drug Action
and Abuse
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Robert B. Raffa
This book will be published in
December of 2008 |
About this bookThe study of drug action has benefitted greatly from the development and use of in vivo model systems. In model systems, manipulations and observations can be more rigorously controlled and screens of novel therapeutic agents can be more safely conducted. No single model system provides all of the possible advantages. At one end, mammalian models allow the study of complex behavioral patterns and the most complex of cognitive functioning. At the other end, models using simple organisms such as C. elegans allow the application of the most sophisticated and recent molecular biology and other innovative techniques. The major purpose of the present book is to highlight another model—one that we believe occupies a uniquely important position. |
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Table of contents1. Planaria: Short Introduction Robert B. Raffa 2. Brain and Neural Networks Kaneyasu Nishimura, Hiroshi Yamamoto, Yoshihisa Kitamura and Kiyokazu Agata 3. Gene Expression in the Brain and Central Nervous System in Planarians Katsuhiko Mineta, Kazuho Ikeo and Takashi Gojobori 4. Catecholamines in Planaria Antonio Carolei, Irene Ciancarelli and Giorgio Venturini 5. Opioids in Planaria Antonio Carolei, Marco Colasanti and Giorgio Venturini 6. Nitric Oxide in Lower Invertebrates Marco Colasanti and Giorgio Venturini 7. Second Messenger Systems in Planaria Scott M. Rawls 8. Planaria as Model in Drug Abuse Research Robert B. Raffa 9. Physical Dependence and Withdrawal in Planarians Robert B. Raffa 10. Drug Combinations and Isoboles Ronald J. Tallarida 11. Analysis of Behavior in the Planarian Model Cindy L. Nicolas, Charles I. Abramson and Michael Levin 12. The Planarian Regeneration Model as a Context for the Study of Drug Effects and Mechanisms Néstor J. Oviedo and Michael Levin | |