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Viruses: Overturning RNA Turnover
Kevin J. Sokoloski, Carol J. Wilusz and Jeffrey Wilusz
volume 3 | issue 4
october/november/december 2006Pages: 140 - 144
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It is becoming clear that viruses interface with the mRNA decay machinery in a variety of ways during an infection. First, RNA viruses in particular must evade the mRNA decay machinery long enough to replicate and establish infection. Second, many viruses usurp or augment cellular mRNA decay pathways to regulate or selectively express their own genes, often inducing massive decay of the host transcriptome. Finally, temporal progression of a viral infection can depend on regulated decay of specific viral transcripts. Therefore, in order to fully understand viral biology, we must take into account the interactions between viruses and the mRNA decay machinery. This approach gives insights into regulatory mechanisms of cellular mRNA decay, as well as revealing novel ways to influence the outcome of viral infections.
Authors
Kevin J. Sokoloski
Colorado State University, Department of Microbiology, Immunology and Pathology; Fort Collilns, CO USA
Carol J. Wilusz
Colorado State University, Department of Microbiology, Immunology and Pathology; Fort Collilns, CO USA
Jeffrey Wilusz
Colorado State University, Department of Microbiology, Immunology and Pathology; Fort Collilns, CO USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.