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Mini Review

Lesion mimic mutants: A classical, yet still fundamental approach to study programmed cell death

Wolfgang Moeder and Keiko Yoshioka

volume 3 | issue 10

october 2008
Pages: 764 - 767

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Over the last decade a substantial number of lesion mimic mutants (LMM) have been isolated and a growing number of the genes have been cloned. It is now becoming clear that these mutants are valuable tools to dissect various aspects of programmed cell death (PCD) and pathogen resistance pathways in plants. Together with other forward genetics approaches LMMs shed light on the PCD machinery in plant cells and revealed important roles for sphingolipids, Ca²⁺ and chloroplast-derived porphyrin-metabolites during cell death development.

Authors

Wolfgang Moeder

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada; Center for the Analysis of Genome Evolution and Function (CAGEF), University of Toronto, Toronto, Ontario, Canada

Keiko Yoshioka