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Article Addendum
From the Notch Signaling Pathway to Ribosome Biogenesis
SierChing Chantha, Faiza Tebbji and Daniel P. Matton
volume 2 | issue 3
may/june 2007Pages: 168 - 170
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Nearly 240 WD repeat proteins have been identified from the Arabidopsis genome. Among these, some well characterized WDR proteins were shown to regulate various developmental processes in plants.1 We have recently isolated in Solanum chacoense a homolog of the Drosophila NOTCHLESS gene. In Drosophila, NOTCHLESS regulates the activity of the Notch signaling pathway through a direct interaction with the intracellular domain of the Notch receptor. Although no Notch signaling pathway exists in plants, the NLE gene is conserved in animals, plants and yeast. Furthermore, functional conservation was suggested by expression of the plant NLE gene in Drosophila. In plants, underexpression of the plant NLE gene altered numerous developmental processes including seed development, and resulted in a reduction in aerial organ size, in organ numbers, in delayed flowering, and in an increased stomatal index. Surprisingly, the link between these pleiotropic phenotypes is the recent discovery of the involvement of NLE in ribosome biogenesis, emphasizing its role in proper cellular growth and proliferation during plant development.
Authors
SierChing Chantha
Université de Montréal, Montréal, Canada
Faiza Tebbji
Université de Montréal, Montréal, Canada
Daniel P. Matton
Institut de recherche en biologie végétale, Université de Montréal
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.





