Epigenetics Jobs

The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organisation with HEFCE RAE ratings of international excellence across all of its research programmes. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from
epidemiology, genetics and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment.

We are seeking a strong candidate for a Career Development (tenure-track) or Career (non-time limited) Faculty position with an excellent track record in epigenetic research and/or anticancer target validation. The successful candidate will lead a thriving research programme focussing on epigenetic target discovery and epigenetic therapies. The team will facilitate interaction with epigenetic profiling and drug discovery/development groups, with the long term objective of identifying novel targets and biological assays for anticancer drug discovery and development, leading to clinical trials that incorporate epigenetic biomarkers.

Substantial initial funding for posts, consumables and equipment will be available. Informal enquiries would be welcomed and should be addressed to: Professor Bob Brown: r.brown@beatson.gla.ac.uk.

To apply, please send two copies of a research plan (up to 4 pages) and a C.V., including the names and contact details of three referees, to the Human Resources Office, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP quoting reference HAD136

The Team Leader job specification is available at www.icr.ac.uk/jobs. Alternatively, please call our 24 hour recruitment line on +44 (0) 207 153 5475

Postdoctoral Positions in Chromatin Epigenetics of an Unusual Type of Muscular Dystrophy
Tulane Medical School, New Orleans, LA

Two positions are available now for up to 3 years to study the chromatin structure and gene expression in a subtelomeric region linked to facioscapulohumeral muscular dystrophy (FSHD). FSHD is a dominant disease caused by having only 1-10 tandem repeats of a 3.3-kb sequence (D4Z4) in the subtelomeric region of the long arm of chromosome 4.

Unaffected individuals have 10-100 copies of this repeat on both homologues of chromosome 4. Because there is little or no expression of this tandem repeat array and there is a gene desert around the DNA repeats, FSHD probably involves long-distance looping interactions
affecting the expression of a distant gene on chromosome 4. The research will include tiling array expression studies of RNA polymerase chromatin immunoprecipitates, analysis of DNA methylation, and assays for long-distance chromatin interactions (chromosome conformation capture).

I am looking for Ph.D. scientists interested in doing challenging and fascinating research supported by the US NIH. Candidates should have astrong research background in molecular genetics.

Melanie Ehrlich
Founder, DNA Methylation Society/Epigenetics Society
Professor, Human Genetics and Biochemistry
Tulane Medical School
New Orleans, LA
ehrlich@tulane.edu