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The official journal of the Epigenetics Society.

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Review

Genomic imprinting in plants

Olivier Garnier, Sylvia Laoueillé-Duprat and Charles Spillane

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Genomic imprinting attracted particular attention in the 1980’s following the discovery that the parental origin of genetic information is essential for normal development of eutherians,1,2 for review see.3 The term imprinting was first introduced in the 1960s to describe the elimination of the paternal chromosomes during spermatogenesis in the Sciarid fly.4‑6 Today the term genomic imprinting mainly refers to parent‑of‑origin specific effects distinguishing each parental genome which can be regarded as memories, or “imprints”.7,8 Breaking the rules of Mendel, genomic imprinting is an epigenetic phenomenon per se. Epigenetics is currently defined as the study of mitotically or meiotically heritable changes in gene expression without any change in DNA sequence9,10 and it is intimately linked to the study of inheritance of chromatin states.11 Gene imprinting currently refers to differential expression of autosomal genes according to their parent of origin.12 The phenomenon of genomic imprinting explains several cases of parent‑specific human disorders.13 To date over 80 imprinted genes have been described in mammals14 and their parent‑of‑origin specific expression can correlate with changes in DNA methylation patterns, antisense noncoding RNAs and chromatin folding.3 Epigenetic imprints can either activate or silence the “imprinted” allele, and hence imprinting can be associated with either an expressed or silenced allele.15 In mammals, the number of paternally expressed imprinted genes is almost equivalent to the number of maternally expressed genes and the imprinted status can differs according to tissue, developmental stage and species. It is then crucial for our understanding to clearly indicate the status of imprinting (i.e., paternally or maternally expressed) and the context (e.g., species, developmental stage, tissue).

Authors

Olivier Garnier

University College Cork

Sylvia Laoueillé-Duprat

University College Cork

Charles Spillane

University College Cork

Purchase article for $19

Subscribe to this journal for $79/year