CSSN: ISSN 1000-467X CODEN: AIZHENG4 CN: 44-1195/R

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Basic Research Paper

Antitumor Effects and Mechanisms of Dendritic Cell Vaccine which Silenced SOCS1 by siRNA, Stimulated by OK432 and Pulsed with Tumor Cell Lysates in Hepatocellular Carcinoma

Hai-Feng Song, Jun Zhou, Ke Pan, Qi-Jing Wang, Hui Wang, Li-Xi Huang, Yong-Qiang Li and Jian-Chuan Xia

volume 27 | issue 7

July 2008
Pages: 15 - 20

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Suppressor of cytokine signaling 1 (SOCS1) plays a critical role in antitumor immunity. Down-regulating SOCS1 in antigen-presenting dendritic cells (DCs) could enhance antigen-specific antitumor immunity. This study was to investigate the antigen-specific antitumor effect of SOCS1-silenced DCs which stimulated by OK432 and pulsed with hepatocellular carcinoma cell line HepG2 antigens, and explore the mechanisms.