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Basic Research Paper

Effects of Mitoxantrone on the Activity of Human Protein Kinase CK2 Holoenzyme

Chun-Mei Li, Xin-Guang Liu, Xiao-Cong Lin, Xiao-Wen Chen and Nian-Ci Liang

Protein kinase CK2, a highly conserved protein serine/threonine kinase that is ubiquitously distributed in eukaryotes, has a close relationship with human leukemia. Mitoxantrone is an effective drug used for acute leukemias. This study was to observe the effects of mitoxantrone on the activity of recombinant human protein kinase CK2 holoenzyme and proliferation in human leukemia cell line HL-60.

Authors

Chun-Mei Li

Guangdong Pharmaceutical College

Xin-Guang Liu

Guangdong Medical College

Xiao-Cong Lin

Guangdong Medical College

Xiao-Wen Chen

Guangdong Medical College and Shenzhen Children's Hospital

Nian-Ci Liang

Guangdong Medical College