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Basic Research Paper

Effects of RNA Interference Targeting Hypoxia-Inducible Factor-1α (HIF-1α) on Chemosensitivity of Human Leukemia Cell Line K562

Bing-Zong Li, Wen-Zhuo Zhuang, Ping Chen and Jin-Xiang Fu

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Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor in anoxic circumstances. Little is known about changes in biological characters of hematological malignancies, especially leukemia. This study was to explore the influence of RNA interference (RNAi) targeting HIF-1α on homoharringtonine (HHT)-sensitivity of human chronic myelogeneous leukemia (CML) K562 cells.

Authors

Bing-Zong Li

Soochow University

Wen-Zhuo Zhuang

Soochow University

Ping Chen

Soochow University

Jin-Xiang Fu

Soochow University

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