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New and Old Functions of STAT3: A Pivitol Target for Individualized Treatment of Cancer

G. Inghirami, R. Chiarle, W.J. Simmons, R. Piva, K. Schlessinger, D.E. Levy
Volume: 4 | Issue: 9 | Pages: 1131 - 1133

Open Access Article

The Role of CREB as a Proto-oncogene in Hematopoiesis

Kentaro Kinjo, Salemiz Sandoval, Kathleen M. Sakamoto and Deepa B. Shankar
Volume: 4 | Issue: 9 | Pages: 1134 - 1135

Open Access Article

Search for Testicular Cancer Gene Hits Dead-End

Angabin Matin and Joseph H. Nadeau
Volume: 4 | Issue: 9 | Pages: 1136 - 1138

Open Access Article

Hedgehogs as Negative Regulators of the Cell Cycle

Carl Neumann
Volume: 4 | Issue: 9 | Pages: 1139 - 1140

Open Access Article

Apoptosis Through Targeted Activation of Caspase8 (“ATTAC-mice”): Novel Mouse Models of Inducible and Reversible Tissue Ablation

Maria E. Trujillo, Utpal B. Pajvani and Philipp E. Scherer
Volume: 4 | Issue: 9 | Pages: 1141 - 1145

Open Access Article

The Making of the Liver: Competence in the Foregut Endoderm and Induction of Liver-Specific Genes

Klaus H. Kaestner
Volume: 4 | Issue: 9 | Pages: 1146 - 1148

Open Access Article

Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo

P. Wagner, B. Wang, E. Clark, H. Lee, R. Rouzier and L. Pusztai
Volume: 4 | Issue: 9 | Pages: 1149 - 1152

Open Access Article

Regulation of HIF by Prolyl hydroxylases: Recruitment of the Candidate Tumor Suppressor Protein ING4

Abdullah Ozer and Richard K. Bruick
Volume: 4 | Issue: 9 | Pages: 1153 - 1156

Open Access Article

Assembly of GMPCPP-Bound Tubulin into Helical Ribbons and Tubes and Effect of Colchicine

Hong-Wei Wang, Sydney Long, K. Rose Finley and Eva Nogales
Volume: 4 | Issue: 9 | Pages: 1157 - 1160

Open Access Article

Perspectives

Ran-GTP regulates Kinetochore Attachment in Somatic Cells

Alexei Arnaoutov and Mary Dasso
Volume: 4 | Issue: 9 | Pages: 1161 - 1165

Open Access Article

ATM-Mediated Phosphorylations Inhibit Mdmx/Mdm2 Stabilization by HAUSP in Favor of p53 Activation

Erik Meulmeester, Yaron Pereg, Yosef Shiloh and Aart G. Jochemsen
Volume: 4 | Issue: 9 | Pages: 1166 - 1170

Open Access Article

Death-From-Cancer Signatures and Stem Cell Contribution to Metastatic Cancer

Gennadi V. Glinsky
Volume: 4 | Issue: 9 | Pages: 1171 - 1175

Open Access Article

Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy

Thomas Helleday, Helen E. Bryant and Niklas Schultz
Volume: 4 | Issue: 9 | Pages: 1176 - 1178

Open Access Article

MicroRNAs: Critical Regulators of Development, Cellular Physiology and Malignancy

Joshua T. Mendell
Volume: 4 | Issue: 9 | Pages: 1179 - 1184

Open Access Article

Crosstalk Between Pten and Ras Signaling Pathways in Tumor Development

Minh D. To, Jesus Perez-Losada, Jian-Hua Mao, Allan Balmain
Volume: 4 | Issue: 9 | Pages: 1185 - 1188

Open Access Article

Activating p38 MAPK: New Tricks for an Old Kinase

Paul R. Mittelstadt, Jesús M. Salvador, Albert J. Fornace, Jr. and Jonathan D. Ashwell
Volume: 4 | Issue: 9 | Pages: 1189 - 1192

Open Access Article

Review

Repair of Double-Strand DNA Breaks by the Human Nonhomologous DNA End Joining Pathway: The Iterative Processing Model

Yunmei Ma, Haihui Lu, Klaus Schwarz and Michael R. Lieber
Volume: 4 | Issue: 9 | Pages: 1193 - 1200

Open Access Article

Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives

Bharat B. Aggarwal and Haruyo Ichikawa
Volume: 4 | Issue: 9 | Pages: 1201 - 1215

Open Access Article

Good Timing in the Cell Cycle for Precise DNA Repair by BRCA1

Stephen T Durant and Jac A Nickoloff
Volume: 4 | Issue: 9 | Pages: 1216 - 1222

Open Access Article

Brief Report

DNA Replication Initiates at Different Sites in Early and Late S Phase within Human Ribosomal RNA Genes

Frederick D. Coffman, Mai He, Mai-Ling Diaz and Stanley Cohen
Volume: 4 | Issue: 9 | Pages: 1223 - 1226

Open Access Article

The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein

Xueyan Zhong, Limin Liu, Ailian Zhao, Gerd P. Pfeifer and Xingzhi Xu
Volume: 4 | Issue: 9 | Pages: 1227 - 1229

Open Access Article

Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase

Ramla Benmaamar and Michele Pagano
Volume: 4 | Issue: 9 | Pages: 1230 - 1232

Open Access Article

Report

CDC25B Phosphorylation by Aurora A Occurs at the G2/M Transition and is Inhibited by DNA Damage

Martine Cazales, Estelle Schmitt, Emilie Montembault, Christine Dozier, Claude Prigent and Bernard Ducommun
Volume: 4 | Issue: 9 | Pages: 1233 - 1238

Open Access Article

The Intracellular Tyrosine Kinase Brk Sensitizes Nontransformed Cells to Inducers of Apoptosis

Andrea Haegebarth, Rafael Nunez and Angela L. Tyner
Volume: 4 | Issue: 9 | Pages: 1239 - 1246

Open Access Article

Blockage of NF-?B Induces Serine 15 Phosphorylation of Mutant p53 by JNK Kinase in Prostate Cancer Cells

Luiz F Zerbini, Yihong Wang, Ricardo G. Correa, Je-Yoel Cho and Towia A Libermann
Volume: 4 | Issue: 9 | Pages: 1247 - 1253

Open Access Article

Human CDK2 Inhibition Modifies the Dynamics of Chromatin-Bound Minichromosome Maintenance Complex and Replication Protein A

Yonghong Zhu, Yukio Ishimi, Marcel Tanudji and Emma Lees
Volume: 4 | Issue: 9 | Pages: 1254 - 1263

Open Access Article

p53 Codon 72 Alleles Influence the Response to Anticancer Drugs in Cells from Aged People by Regulating the Cell Cycle Inhibitor p21^WAF1

Stefano Salvioli, Massimiliano Bonafé, Cristiana Barbi, Gianluca Storci, Chiara Trapassi, Francesca Tocco, Silvia Gravina, Matteo Rossi, Luca Tiberi, Chiara Mondello, Daniela Monti and Claudio Franceschi
Volume: 4 | Issue: 9 | Pages: 1264 - 1271

Open Access Article

Retinoblastoma Family 2 is Required In Vivo for the Tissue-Specific Repression of dE2F2 target Genes

Olivier Stevaux, Dessislava K. Dimova, Jun-Yuan Ji, Nam Sung Moon, Maxim V. Frolov and Nicholas J. Dyson
Volume: 4 | Issue: 9 | Pages: 1272 - 1280

Open Access Article

APOBEC4, a New Member of the AID/APOBEC Family of Polynucleotide (Deoxy)Cytidine Deaminases Predicted by Computational Analysis

Igor B. Rogozin, Malay K. Basu, I. King Jordan, Youri I. Pavlov and Eugene V. Koonin
Volume: 4 | Issue: 9 | Pages: 1281 - 1285

Open Access Article

Role of the Cell Cycle in the Pathobiology of Central Nervous System Trauma

Ibolja Cernak, Bogdan Stoica, Kimberly R. Byrnes, Simone Di Giovanni and Alan I. Faden
Volume: 4 | Issue: 9 | Pages: 1286 - 1293

Open Access Article

Topoisomerase II Suppresses the Temperature Sensitivity of Saccharomyces cerevisiae pds5 Mutants, but not the Defect in Sister Chromatid Cohesion

Cristina Aguilar, Christian Davidson, Melissa Dix, Kristen Stead, Ke Zheng, Theresa Hartman and Vincent Guacci
Volume: 4 | Issue: 9 | Pages: 1294 - 1304

Open Access Article