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Aurora B kinases restrict chromosome decondensation to telophase of mitosis

Amit C.J. Vas and Duncan J. Clarke

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The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome segregation. Vertebrates have three Aurora kinases, Aurora-A, -B and -C, while invertebrates have only Aurora-A and -B and yeasts have a single Aurora kinase, Ipl1 in S. cerevisiae and Ark1 in S. pombe. Recently, the role of Aurora kinases in chromosome condensation has been defined; Aurora B plays a crucial role in the axial shortening of chromosomes during anaphase, presumably in order to prevent chromosome arms from becoming trapped within the cytokinetic plate.

Authors

Amit C.J. Vas

University of Minnesota Medical School; Minneapolis, MN

Duncan J. Clarke

University of Minnesota Medical School; Minneapolis, MN

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