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A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle, and cancer
Richard K. Assoian and Yuval Yung
volume 7 | issue 1
1 January 2008Pages: 24 - 27
This is an open-access article
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The identification of Skp2 as a direct E2F target has allowed us to document the existence of a positive feedback loop comprised of Rb-E2F, Skp2, p27 and cyclin E-cdk2. We have termed this set of regulatory molecules the Skp2 autoinduction loop. Interference with this loop selectively regulates cell cycle progression through the restriction point. We describe here how the Skp2 autoinduction loop may interact with other regulatory controls on the restriction point, and how the reciprocal relationship between Rb and Skp2 may affect signal transduction to the cell cycle and thinking about the role of Skp2 over-expression in cancers.
Authors
Richard K. Assoian
University of Pennsylvania School of Medicine; Philadelphia, PA
Yuval Yung
University of Pennsylvania School of Medicine; Philadelphia, PA
This is an open-access article
Download PDFIf the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.