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β2-Chimaerin in Cancer Signaling: Connecting Cell Adhesion and MAP Kinase Activation

Stephen P. Bruinsma and Thomas J. Baranski

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The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates β2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.

Authors

Stephen P. Bruinsma

Washington University School of Medicine; St. Louis, MO

Thomas J. Baranski

Washington University School of Medicine; St. Louis, MO

Purchase article for $19

Subscribe to this journal for $129/year