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Chromosomal Instability in Cancer: Causality and Interdependence
Ashok R. Venkitaraman
volume 6 | issue 19
1 October 2007Pages: 2341 - 2343
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Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.
Authors
Ashok R. Venkitaraman
University of Cambridge; Cambridge UK
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.